Radiation-Induced Neuroinflammation and Radiation Somnolence Syndrome
Por:
Ballesteros-Zebadúa P., Chavarria A., Celis M.A., Paz C., Franco-Pérez J.
Publicada:
1 nov 2012
Resumen:
Cranial irradiation remains a standard treatment for malignant and benign brain diseases. Although this procedure helps to lengthen the life expectancy of the patient, the appearance of adverse effects related to radiation-induced injury is inevitable. Radiation somnolence syndrome (RSS) has been described as a delayed effect observed mainly after whole-brain radiotherapy in children. The RSS was first linked to demyelination, but more recently it has been proposed that the inflammatory response plays a primary role in the aforementioned syndrome. To evaluate the feasibility of this hypothesis, we explored previous work about RSS and reviewed published research that included measurements of the inflammatory response in models of brain exposure to ionizing radiation. Pro-inflammatory cytokines such as interleukin-1 beta, tumor necrosis factor-alpha, interleukin-6 and interleukin-18 as well as other inflammatory markers such as cyclooxygenase-2, prostaglandin E-2, glial fibrillary acid p
Filiaciones:
Ballesteros-Zebadúa P.:
Univ Nacl Autonoma Mexico, Biomed Sci PhD Program, Mexico City 04510, DF, Mexico
Chavarria A.:
Univ Nacl Autonoma Mexico, Sch Med, Dept Expt Med, Col Doctores 06726, DF, Mexico
Celis M.A.:
Radiosurgery Unit, National Institute of Neurology and Neurosurgery, Insurgentes Sur No. 3877, Col. La Fama, C.P. 14269, México D.F., Mexico
Paz C.:
Department of Neurophysiology, National Institute of Neurology and Neurosurgery and Neurosurgery M.V.S, Insurgentes Sur No. 3877, Col. La Fama, C.P. 14269, México D.F., Mexico
Franco-Pérez J.:
Department of Neurophysiology, National Institute of Neurology and Neurosurgery and Neurosurgery M.V.S, Insurgentes Sur No. 3877, Col. La Fama, C.P. 14269, México D.F., Mexico
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