Characterization of Single-Nucleotide Polymorphisms in the Tumor Necrosis Factor alpha Promoter Region and in Lymphotoxin alpha in Squamous Intraepithelial Lesions, Precursors of Cervical Cancer
Por:
Nieves-Ramirez M.E., Partida-Rodriguez O., Alegre-Crespo P.E., Tapia-Lugo M.C., Perez-Rodriguez M.E.
Publicada:
1 dic 2011
Resumen:
Development of cervical cancer is a long process of abnormal cancerous cell growth in the cervix and is primarily the result of infection with specific high-risk types of human papillomavirus (HPV). The cytokines tumor necrosis factor alpha (TNF alpha) and lymphotoxin alpha (LTA) have an important role in all stages of cervical cancer and have the ability to induce the regression or promote the development of human tumors. Biologically important single-nucleotide polymorphisms (SNPs) occur within the TNF alpha and LTA genes. Therefore, the purpose of this study was to investigate the SNPs in the TNFa promoter region (-163, -238, -244, -308, -376, -857, -863, and -1031) and in the first intron of LTA (+252) in women with precursor lesions of cervical cancer. Overall, we studied 396 women from Mexico City. A total of 191 patients with HPV infection and precursor cervical lesions were subdivided in two groups: those with low-grade squamous intraepithelial lesions (n = 132) and those with
Filiaciones:
Nieves-Ramirez M.E.:
Immunology Research Unit, CMN S-XXI, Mexican Social Security Institute, Pediatric Hospital, Cuauhtémoc 330, 3rd Floor, Col Doctores, CP 06720, Mexico City, Mexico
Partida-Rodriguez O.:
Immunology Research Unit, CMN S-XXI, Mexican Social Security Institute, Pediatric Hospital, Cuauhtémoc 330, 3rd Floor, Col Doctores, CP 06720, Mexico City, Mexico
Alegre-Crespo P.E.:
Displasia Clinic Hospital 'Venados', Mexican Social Security Institute, Mexico City, Mexico
Tapia-Lugo M.C.:
Displasia Clinic Hospital 'Venados', Mexican Social Security Institute, Mexico City, Mexico
Perez-Rodriguez M.E.:
Immunology Research Unit, CMN S-XXI, Mexican Social Security Institute, Pediatric Hospital, Cuauhtémoc 330, 3rd Floor, Col Doctores, CP 06720, Mexico City, Mexico
All Open Access, Gold
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