Mexican mestizo population sub-structure: effects on genetic and forensic statistical parameters
Por:
Noris G., Santana C., Meraz-Ríos M.A., Munoz, MD, Majluf-Cruz A., Magana, JJ, Granados J., Quezada R., Revilla M.C., Martínez-Salas S., Xihuitl S., de la Escalera, GM, Díaz-Badillo A., Calderon-Aranda E.S., Gómez R.
Publicada:
1 dic 2012
Resumen:
Since Mexican mestizos are an admixed population, it is necessary to determine the effects that the substructure of the population has on genetic and forensic parameters. With this aim, a study was performed with 15 STR loci (CODIS plus D2S1338 and D19S433) on 1,640 unrelated Mexican mestizos. We determine allele and genotypic frequencies observing departure from Hardy-Weinberg expectation (12 out of 15 loci, with an excess of homozygotes, Fis > 0), as well as pairs of loci in an apparent linkage disequilibrium (13 of 92 loci). We conducted a test for genetic population stratification, the results show that the Mexican mestizo population is substructured into three subgroups, which are in HW and linkage equilibrium. The combination of the 15 loci in the whole population has high forensic efficiency with the capacity to genetically discriminate one individual in one quintillion (1/10(18)). Our data potentially validates the use of these 15 STR loci to establish forensic identity and par
Filiaciones:
Univ Nacl Autonoma Mexico, Inst Neurobiol, Queretaro, Mexico
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