Polymerized-Type I Collagen Induces Upregulation of Foxp3-Expressing CD4 Regulatory T Cells and Downregulation of IL-17-Producing CD4(+) T Cells (Th17) Cells in Collagen-Induced Arthritis
Por:
Furuzawa-Carballeda J., MacIp-Rodríguez P., Galindo-Feria A.S., Cruz-Robles D., Soto-Abraham V., Escobar-Hernández S., Aguilar D., Alpizar-Rodríguez D., Férez-Blando K., Llorente L.
Publicada:
1 ene 2012
Resumen:
Previous studies showed that polymerized-type I collagen (polymerized collagen) exhibits potent immunoregulatory properties. This work evaluated the effect of intramuscular administration of polymerized collagen in early and established collagen-induced arthritis (CIA) in mice and analyzed changes in Th subsets following therapy. Incidence of CIA was of 100% in mice challenged with type II collagen. Clinimorphometric analysis showed a downregulation of inflammation after administration of all treatments (P < 0.05). Histological analysis showed that the CIA-mice group had extensive bone erosion, pannus and severe focal inflammatory infiltrates. In contrast, there was a remarkable reduction in the severity of arthritis in mice under polymerized collagen, methotrexate or methotrexate/polymerized collagen treatment. Polymerized Collagen but not methotrexate induced tissue joint regeneration. Polymerized Collagen and methotrexate/polymerized collagen but not methotrexate alone induces downr
Filiaciones:
Furuzawa-Carballeda J.:
Department of Immunology, Rheumatology Instituto Nacional de Ciencias Médicas y Nutricin Salvador, Colonia Seccin XVI, Zubirán Vasco de Quiroga No. 15, Tlalpan 14000, Mexico
MacIp-Rodríguez P.:
Department of Immunology, Rheumatology Instituto Nacional de Ciencias Médicas y Nutricin Salvador, Colonia Seccin XVI, Zubirán Vasco de Quiroga No. 15, Tlalpan 14000, Mexico
Galindo-Feria A.S.:
Department of Immunology, Rheumatology Instituto Nacional de Ciencias Médicas y Nutricin Salvador, Colonia Seccin XVI, Zubirán Vasco de Quiroga No. 15, Tlalpan 14000, Mexico
Cruz-Robles D.:
Department of Pathology Instituto Nacional de Cardiología Ignacio, Chávez Juan Badiano No. 1, Colonia Seccin XVI, Tlalpan 14080, Mexico
Soto-Abraham V.:
Department of Pathology Instituto Nacional de Cardiología Ignacio, Chávez Juan Badiano No. 1, Colonia Seccin XVI, Tlalpan 14080, Mexico
Escobar-Hernández S.:
Department of Pathology Instituto Nacional de Cardiología Ignacio, Chávez Juan Badiano No. 1, Colonia Seccin XVI, Tlalpan 14080, Mexico
Aguilar D.:
Department of Experimental Pathology, Instituto Nacional de Ciencias Médicas y Nutricin Salvador, Zubirán Vasco de Quiroga No. 15, Colonia Seccin XVI, Tlalpan 14000, Mexico
Alpizar-Rodríguez D.:
Department of Immunology, Rheumatology Instituto Nacional de Ciencias Médicas y Nutricin Salvador, Colonia Seccin XVI, Zubirán Vasco de Quiroga No. 15, Tlalpan 14000, Mexico
Férez-Blando K.:
Department of Immunology, Rheumatology Instituto Nacional de Ciencias Médicas y Nutricin Salvador, Colonia Seccin XVI, Zubirán Vasco de Quiroga No. 15, Tlalpan 14000, Mexico
Llorente L.:
Department of Immunology, Rheumatology Instituto Nacional de Ciencias Médicas y Nutricin Salvador, Colonia Seccin XVI, Zubirán Vasco de Quiroga No. 15, Tlalpan 14000, Mexico
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