Retinoic acid receptor beta deficiency reduces splenic dendritic cell population in a conditional mouse line
Por:
Serafin-Higuera N., Hernandez-Sanchez J., Ocadiz-Delgado R., Vazquez-Hernandez J., Albino-Sanchez M.E., Hernandez-Pando R., Gariglio P.
Publicada:
30 ago 2012
Resumen:
Different studies have shown that retinoids and their receptors [retinoic acid receptors (RARs) and retinoid X receptors (RXRs)] have crucial effects on the differentiation and function of myeloid cells such as Dendritic cells (DCs) and the development of lymphoid tissue. However, the relationship between RAR beta expression and DCs has not been previously studied in vivo. This work examined the effect of decreased RAR beta expression on the number (and probably on differentiation) of splenic DCs and the structure of spleen using a conditional mouse that partially ablates foxed RAR beta gene (RAR beta(L-/L-) mice). Our results showed that RAR beta is expressed mainly in cells of the splenic White Pulp (WP) zone of Wild type mice. As expected, low levels of RAR beta expression were detected in the spleen of RAR beta(L-/L-) conditional mice. These results were consistent with a decrease in the population of splenic CD11c(+)MHC-II+ cells. Histopathological analyses of conditional mice spl
Filiaciones:
Dept. of Genetics and Molecular Biology, CINVESTAV-IPN, 07360, Mexico, DF, Mexico
Tecnológico de Estudios Superiores de Huixquilucan, 52773, Estado de Mexico, Mexico
Dept. of Pathology, INCMNSZ, 1400, Mexico, DF, Mexico
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