Potential cytotoxic and amoebicide activity of first row transition metal compounds with 2,9-bis-(2 ',5 '-diazahexanyl)-1,1-phenanthroline (L1)
Por:
García-Ramos J.C., Toledano-Magaña Y., Talavera-Contreras L.G., Flores-Álamo M., Ramírez-Delgado V., Morales-León E., Ortiz-Frade L., Gutiérrez A.G., Vázquez-Aguirre A., Mejía C., Carrero J.C., Laclette J.P., Moreno-Esparza R., Ruiz-Azuara L.
Publicada:
1 ene 2012
Categoría:
Inorganic Chemistry
Resumen:
A new synthetic pathway was reported to obtain N6 donor ligand 2,9-bis-(2',5'-diazahexanyl)-1,10-phenanthroline (L1) and its coordination compounds of essential divalent metal ions Mn, Fe, Co, Ni, Cu and Zn. Complete characterization of all compounds was done with the conventional techniques. Crystal structures of [NiL1](PF6)(2) and [ZnL1](PF6)(2)center dot H2O were also reported. Electrochemical studies have shown an active participation of the aromatic moiety of the ligand in redox reactions. The in vitro tests of the cytotoxic activity against human tumour cell lines HeLa (cervix) and CHP-212 (neuroblastoma) showed that all coordination compounds that involve redox active metal ions exhibit noteworthy antiproliferative activity, superior in all cases to cisplatin. [CuL1](2+) showed the lower IC50 value in the HeLa cell line with 1.84 mu M, meanwhile, [CoL1](2+) showed the lower value in neuroblastoma CHP-212 with IC50 = 45.28 mu M. None of these compounds were active against the SK-
Filiaciones:
García-Ramos J.C.:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Quim Inorgan & Nucl, Mexico City 04510, DF, Mexico
Toledano-Magaña Y.:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mexico City 04510, DF, Mexico
Talavera-Contreras L.G.:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Quim Inorgan & Nucl, Mexico City 04510, DF, Mexico
Flores-Álamo M.:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Quim Inorgan & Nucl, Mexico City 04510, DF, Mexico
Ramírez-Delgado V.:
Electrochemistry Department, Centro de Investigación y Desarrollo Tecnológico en Electroquímica, S.C. Parque Tecnológico Querétaro, C.P. 76703, Querétaro, Mexico
Morales-León E.:
Electrochemistry Department, Centro de Investigación y Desarrollo Tecnológico en Electroquímica, S.C. Parque Tecnológico Querétaro, C.P. 76703, Querétaro, Mexico
Ortiz-Frade L.:
Electrochemistry Department, Centro de Investigación y Desarrollo Tecnológico en Electroquímica, S.C. Parque Tecnológico Querétaro, C.P. 76703, Querétaro, Mexico
Gutiérrez A.G.:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mexico City 04510, DF, Mexico
Vázquez-Aguirre A.:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mexico City 04510, DF, Mexico
Mejía C.:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mexico City 04510, DF, Mexico
Carrero J.C.:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mexico City 04510, DF, Mexico
Laclette J.P.:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mexico City 04510, DF, Mexico
Moreno-Esparza R.:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Quim Inorgan & Nucl, Mexico City 04510, DF, Mexico
Ruiz-Azuara L.:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Quim Inorgan & Nucl, Mexico City 04510, DF, Mexico
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