Casein induces the proliferation of bone marrow mononuclear cells, apoptosis of WEHI-3 leukaemic cells and increased survival in a leukaemia mouse model
Por:
Ledesma-Martínez E., Pérez-Cordero C., Córdova-Galaviz Y., Sánchez-Tellez G., Huerta-Yepez S., Aguiniga-Sanchez, I, Miranda-Peralta E., Monroy-García A., Weiss-Steider B., Santiago-Osorio E.
Publicada:
1 sep 2012
Resumen:
Acute myeloid leukaemia results from the neoplastic transformation of haematopoietic stem cells. Although advances have been made in its treatment, the mortality rate remains high. As a result, therapeutic alternatives continue to be explored. In this study, we present evidence that suggests that casein, the principal protein in milk, possesses significant antileukaemic properties. We investigated whether casein inhibited the in vitro proliferation and induced the apoptosis of the mouse myelomonocytic leukaemia cell line WEHI-3. By contrast, under identical conditions, casein markedly promotes the proliferation of mouse normal mononuclear bone marrow cells. Since the selective elimination of leukaemia cells is an ideal therapeutic strategy, we also evaluated the antileukaemic potential of casein in vivo. The results showed that casein increases the survival of mice bearing WEHI-3-induced tumours, suggesting that this molecule is also capable of inhibiting the proliferation of these cel
Filiaciones:
Ledesma-Martínez E.:
Univ Nacl Autonoma Mexico, Hematopoiesis & Leukaemia Lab, Res Unit Cell Differentiat & Canc, Mexico City 09230, DF, Mexico
Pérez-Cordero C.:
Univ Nacl Autonoma Mexico, Hematopoiesis & Leukaemia Lab, Res Unit Cell Differentiat & Canc, Mexico City 09230, DF, Mexico
Córdova-Galaviz Y.:
Univ Nacl Autonoma Mexico, Hematopoiesis & Leukaemia Lab, Res Unit Cell Differentiat & Canc, Mexico City 09230, DF, Mexico
Sánchez-Tellez G.:
Univ Nacl Autonoma Mexico, Hematopoiesis & Leukaemia Lab, Res Unit Cell Differentiat & Canc, Mexico City 09230, DF, Mexico
Huerta-Yepez S.:
Research Unit in Oncological Diseases, Childhood Hospital of Mexico 'Federico Gómez', Mexico
Aguiniga-Sanchez, I:
Univ Nacl Autonoma Mexico, Hematopoiesis & Leukaemia Lab, Res Unit Cell Differentiat & Canc, Mexico City 09230, DF, Mexico
Miranda-Peralta E.:
Cancer Research Unit, Oncology Hospital, Mexico
Monroy-García A.:
Univ Nacl Autonoma Mexico, Immunobiol Lab, Res Unit Cell Differentiat & Canc, Mexico City 09230, DF, Mexico
Weiss-Steider B.:
Univ Nacl Autonoma Mexico, Hematopoiesis & Leukaemia Lab, Res Unit Cell Differentiat & Canc, Mexico City 09230, DF, Mexico
Santiago-Osorio E.:
Univ Nacl Autonoma Mexico, Hematopoiesis & Leukaemia Lab, Res Unit Cell Differentiat & Canc, Mexico City 09230, DF, Mexico
All Open Access, Bronze
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