Gene expression profiles induced by E6 from non-European HPV18 variants reveals a differential activation on cellular processes driving to carcinogenesis
Por:
Fragoso-Ontiveros V., Alvarez-Garcia, RM, Contreras-Paredes A., Vaca-Paniagua F., Herrera, LA, López-Camarillo C., Jacobo-Herrera N., Lizano-Soberón M., Pérez-Plasencia C.
Publicada:
10 oct 2012
Categoría:
Virology
Resumen:
Cervical cancer in developed countries remains as a major concern on public health policies due to incidence and mortality rates. Persistent infection with high risk human papillomavirus is a necessary etiological agent in the progression to invasive cervical carcinoma. A proposed hypothesis is the association between more aggressive HPV variants and the risk to develop cervical cancer. In order to have a global perspective in terms of cellular transcripts and molecular pathways affected by HPV18 E6 intratype variants; we conducted a genome wide analysis of gene expression. Our results show that E6 derived from non-European variants are able to up-regulate cellular transcripts associated to the hallmarks of cancer; such as cell cycle, migration, Wnt pathway and mTor signaling. Moreover, we were able to show that HPV18 E6 from African variant had a major effect on cellular processes such as cell cycle and migration as confirmed by functional studies. © 2012 Elsevier Inc.
Filiaciones:
Fragoso-Ontiveros V.:
Laboratorio de Genómica, Instituto Nacional de Cancerología, Av. San Fernando 22, Col. Sección XVI, C.P. 14080 Tlalpan, D.F., Mexico
Contreras-Paredes A.:
Univ Nacl Autonoma Mexico, Unidad Invest Biomed Canc, Inst Nacl Cancerol, Inst Invest Biomed, Tlalpan 14080, DF, Mexico
Vaca-Paniagua F.:
Laboratorio de Genómica, Instituto Nacional de Cancerología, Av. San Fernando 22, Col. Sección XVI, C.P. 14080 Tlalpan, D.F., Mexico
Herrera, LA:
Univ Nacl Autonoma Mexico, Unidad Invest Biomed Canc, Inst Nacl Cancerol, Inst Invest Biomed, Tlalpan 14080, DF, Mexico
López-Camarillo C.:
UACM, Posgrado en Ciencias Genómicas. Benito Juárez, México, Av. San Lorenzo 290, Col. Del Valle Sur, C.P. 03100 Benito Juárez, D.F., Mexico
Jacobo-Herrera N.:
INCMNSZ, Unidad de Bioquímica, Tlalpan, D. F. Vasco de Quiroga 15, Colonia Seccion XVI, Tlalpan C.P. 14080, D.F., Mexico
Lizano-Soberón M.:
Univ Nacl Autonoma Mexico, Unidad Invest Biomed Canc, Inst Nacl Cancerol, Inst Invest Biomed, Tlalpan 14080, DF, Mexico
Pérez-Plasencia C.:
Univ Nacl Autonoma Mexico, FES IZTACALA, Unidad Biomed, Los Reyes Iztacala 54090, Tlanepantla, Mexico
All Open Access; Bronze
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