The post-synaptic glycine receptor mediates in a transitory and sustained way the glycinergic inhibition in the vertebrate retina
Por:
Velazquez-Flores, MA, Salceda, R
Publicada:
1 jul 2012
Categoría:
Neurology (clinical)
Resumen:
Introduction. Glycine and the ?-aminobutyric acid are the principal inhibitory neurotransmitters in the vertebrate retina. The inhibitory action of glycine is mediated by the post-synaptic glycine receptor, a chloride-selective channel, constituted by three ß and two a subunits (a 1- a 4), which is antagonized by the alkaloid strychnine. In the retina, it is known that all a isoforms are expressed at the level of the inner synaptic layer with a very low colocalization. The glycine receptor formed by either a 1 or a 3 shows rapid kinetics, whereas a 2 or a 4 receptors respond tonically. The use of transgenic mice has allowed the study of the different glycine receptor a subunits in the glycinegic neurotransmission of the mammalian retina. Aim. To describe the participation of the glycine receptor in the inhibitory neurotransmission particularly in the retina. Development. In this review we describe the experiments that have allowed the localization and the involvement of the a subunit isoforms in specific transmission circuits of the vertebrate retina. Conclusions. The localization of the glycine receptor conformed by different isoforms of the a subunit in specific neuronal types, indicate the presence of glycinergic circuits that encode information differently in the retina. © 2012.
Filiaciones:
Univ Nacl Autonoma Mexico, Div Neurociencias, Inst Fisiol Celular, Mexico City 04510, DF, Mexico
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