Disease Severity in Patients Infected with Leishmania mexicana Relates to IL-1 beta
Por:
Fernández-Figueroa E.A., Rangel-Escareño C., Espinosa-Mateos V., Carrillo-Sánchez K., Salaiza-Suazo N., Carrada-Figueroa G., March-Mifsut S., Becker I.
Publicada:
1 may 2012
Resumen:
Leishmania mexicana can cause both localized (LCL) and diffuse (DCL) cutaneous leishmaniasis, yet little is known about factors regulating disease severity in these patients. We analyzed if the disease was associated with single nucleotide polymorphisms (SNPs) in IL-1 beta (-511), CXCL8 (-251) and/or the inhibitor IL-1RA (+2018) in 58 Mexican mestizo patients with LCL, 6 with DCL and 123 control cases. Additionally, we analyzed the in vitro production of IL-1 beta by monocytes, the expression of this cytokine in sera of these patients, as well as the tissue distribution of IL-1 beta and the number of parasites in lesions of LCL and DCL patients. Our results show a significant difference in the distribution of IL-1 beta (-511 C/T) genotypes between patients and controls (heterozygous OR), with respect to the reference group CC, which was estimated with a value of 3.23, 95% CI = (1.2, 8.7) and p-value = 0.0167), indicating that IL-1 beta (-511 C/T) represents a variable influencing the r
Filiaciones:
Fernández-Figueroa E.A.:
Univ Nacl Autonoma Mexico, Dept Expt Med, Fac Med, Mexico City 04510, DF, Mexico
Rangel-Escareño C.:
Instituto Nacional de Medicina Genómica, México Distrito Federal, Mexico
Espinosa-Mateos V.:
Instituto Nacional de Medicina Genómica, México Distrito Federal, Mexico
Carrillo-Sánchez K.:
Instituto Nacional de Medicina Genómica, México Distrito Federal, Mexico
Salaiza-Suazo N.:
Univ Nacl Autonoma Mexico, Dept Expt Med, Fac Med, Mexico City 04510, DF, Mexico
Carrada-Figueroa G.:
Secretaría de Salud del Estado de Tabasco, Universidad Juárez Autónoma de Tabasco, Tabasco, Mexico
Universidad Juárez Autónoma, de Tabasco, Tabasco, Mexico
March-Mifsut S.:
Instituto Nacional de Medicina Genómica, México Distrito Federal, Mexico
Becker I.:
Univ Nacl Autonoma Mexico, Dept Expt Med, Fac Med, Mexico City 04510, DF, Mexico
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