FUNCTIONAL INTERACTIONS BETWEEN THE PARAVENTRICULAR HYPOTHALAMIC NUCLEUS AND RAPHE MAGNUS. A COMPARATIVE STUDY OF AN INTEGRATED HOMEOSTATIC ANALGESIC MECHANISM
Por:
Condés-Lara M., Rojas-Piloni G., Martínez-Lorenzana G., Diez-Martínez D.C., Rodríguez-Jiménez J.
Publicada:
3 may 2012
Categoría:
Neuroscience (miscellaneous)
Resumen:
This work compares the effects of electrical stimulation of the paraventricular hypothalamic nucleus (PVN) and the raphe magnus nucleus (RMg) on the single-unit response from dorsal spinal cord neurons activated by nociceptive receptive field stimulation. We evaluated the effects of stimulating the PVN or RMg individually or simultaneously, as well as PVN stimulation after RMg electrolytic lesion. PVN or RMg stimulation suppressed the A-delta, C fiber, and post-discharge, and we demonstrated that their simultaneous stimulation increases the duration and intensity of suppressive effects. RMg lesion increased the peripheral responses, but PVN stimulation continued to be suppressive. The intrathecal administration of 20 mu l of a 10(-5) M solution of a specific oxytocin antagonist strongly reduced the PVN effects, and 20 mu l of 10(-6) M naloxone significantly reduced the RMg suppression of receptive field responses. Some spinal cord cells presented a short-latency, evoked action potentia
Filiaciones:
Condés-Lara M.:
Univ Nacl Autonoma Mexico, Inst Neurobiol, Dept Neurobiol Desarrollo & Neurofisiol, Queretaro 76230, Mexico
Rojas-Piloni G.:
Univ Nacl Autonoma Mexico, Inst Neurobiol, Dept Neurobiol Desarrollo & Neurofisiol, Queretaro 76230, Mexico
Martínez-Lorenzana G.:
Univ Nacl Autonoma Mexico, Inst Neurobiol, Dept Neurobiol Desarrollo & Neurofisiol, Queretaro 76230, Mexico
Diez-Martínez D.C.:
Facultad de Medicina, Universidad Autónoma de Querétaro, Querétaro, Mexico
Rodríguez-Jiménez J.:
Univ Nacl Autonoma Mexico, Inst Neurobiol, Dept Neurobiol Desarrollo & Neurofisiol, Queretaro 76230, Mexico
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