Homocysteine is Related to Aortic Mineralization in Patients with Ischemic Heart Disease
Por:
Pena-Duque, MA, Banos-Gonzalez, MA, Valente-Acosta B., Rodríguez-Lobato L.G., Martínez-Ríos M.A., Cardoso-Saldaña G., Barragán-García R., Herrera-Alarcón V., Linares-López C., Delgado-Granados H., de la Pena-Diaz, A
Publicada:
1 ene 2012
Resumen:
Homocysteine is implicated as an early atherosclerotic promoter, which enhances the smooth muscle cell proliferation and produces free radicals that induce cellular damage. These factors must have a role in the progression of atherosclerosis that subsequently leads to vascular mineralization. Aim: Identify a correlation between the plasma concentration of total homocysteine and the amount of minerals that accumulate in the aorta of patients with atherosclerosis. Methods: We performed a cross-sectional study in 13 patients with three-vessel coronary artery disease, undergoing coronary artery bypass surgery. Aortic and mammary artery specimens were analyzed using a scanning electron microscope with an energy dispersive X-ray spectrometer. The homocysteine was determined using an immunonephelometry method. Results: The amount of minerals in the aorta was greater (300 +/- 181.6 particles per 500 mu m(2)) than that in the mammary artery (64 +/- 45 particles per 500 mu m(2)) (p<0.01). The av
Filiaciones:
Valente-Acosta B.:
Univ Nacl Autonoma Mexico, Dept Farmacol, Fac Med, Mexico City 04510, DF, Mexico
Instituto Nacional de Cardiología Ignacio Chávez, Grupo Genética Intervencionista, Departamentos de Biología Molecular, Hemodinámica, Endocrinología, Cirugía, Mexico
Facultad de Medicina, Departamento de Farmacología, Universidad Nacional Autónoma de México, Mexico
Rodríguez-Lobato L.G.:
Instituto Nacional de Cardiología Ignacio Chávez, Grupo Genética Intervencionista, Departamentos de Biología Molecular, Hemodinámica, Endocrinología, Cirugía, Mexico
Martínez-Ríos M.A.:
Instituto Nacional de Cardiología Ignacio Chávez, Grupo Genética Intervencionista, Departamentos de Biología Molecular, Hemodinámica, Endocrinología, Cirugía, Mexico
Cardoso-Saldaña G.:
Instituto Nacional de Cardiología Ignacio Chávez, Grupo Genética Intervencionista, Departamentos de Biología Molecular, Hemodinámica, Endocrinología, Cirugía, Mexico
Barragán-García R.:
Instituto Nacional de Cardiología Ignacio Chávez, Grupo Genética Intervencionista, Departamentos de Biología Molecular, Hemodinámica, Endocrinología, Cirugía, Mexico
Herrera-Alarcón V.:
Instituto Nacional de Cardiología Ignacio Chávez, Grupo Genética Intervencionista, Departamentos de Biología Molecular, Hemodinámica, Endocrinología, Cirugía, Mexico
Linares-López C.:
Univ Nacl Autonoma Mexico, Inst Geofis, Mexico City 04510, DF, Mexico
Instituto de Geofisica, Universidad Nacional Autónoma de Mexico, Mexico
Delgado-Granados H.:
Univ Nacl Autonoma Mexico, Inst Geofis, Mexico City 04510, DF, Mexico
Instituto de Geofisica, Universidad Nacional Autónoma de Mexico, Mexico
de la Pena-Diaz, A:
Univ Nacl Autonoma Mexico, Dept Farmacol, Fac Med, Mexico City 04510, DF, Mexico
All Open Access; Bronze
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