Amplified Genes May Be Overexpressed, Unchanged, or Downregulated in Cervical Cancer Cell Lines
Por:
Vazquez-Mena O., Medina-Martinez I., Juárez-Torres E., Barrón V., Espinosa A., Villegas-Sepulveda N., Gómez-Laguna L., Nieto-Martínez K., Orozco L., Roman-Basaure E., Cortez, SM, Ibanez, MB, Venegas-Vega C., Guardado-Estrada M., Rangel-López A., Kofman S., Berumen J.
Publicada:
7 mar 2012
Resumen:
Several copy number-altered regions (CNAs) have been identified in the genome of cervical cancer, notably, amplifications of 3q and 5p. However, the contribution of copy-number alterations to cervical carcinogenesis is unresolved because genome-wide there exists a lack of correlation between copy-number alterations and gene expression. In this study, we investigated whether CNAs in the cell lines CaLo, CaSki, HeLa, and SiHa were associated with changes in gene expression. On average, 19.2% of the cell-line genomes had CNAs. However, only 2.4% comprised minimal recurrent regions (MRRs) common to all the cell lines. Whereas 3q had limited common gains (13%), 5p was entirely duplicated recurrently. Genome-wide, only 15.6% of genes located in CNAs changed gene expression; in contrast, the rate in MRRs was up to 3 times this. Chr 5p was confirmed entirely amplified by FISH; however, maximum 33.5% of the explored genes in 5p were deregulated. In 3q, this rate was 13.4%. Even in 3q26, which h
Filiaciones:
Vazquez-Mena O.:
Univ Nacl Autonoma Mexico, Fac Med, Hosp Gen Mexico, Unidad Med Genom, Mexico City 04510, DF, Mexico
Unidad de Medicina Genómica, Facultad de Medicina, Hospital General de México, Universidad Nacional Autónoma de México, México, Distrito Federal, Mexico
Medina-Martinez I.:
Univ Nacl Autonoma Mexico, Fac Med, Hosp Gen Mexico, Unidad Med Genom, Mexico City 04510, DF, Mexico
Unidad de Medicina Genómica, Facultad de Medicina, Hospital General de México, Universidad Nacional Autónoma de México, México, Distrito Federal, Mexico
Juárez-Torres E.:
Univ Nacl Autonoma Mexico, Fac Med, Hosp Gen Mexico, Unidad Med Genom, Mexico City 04510, DF, Mexico
Unidad de Medicina Genómica, Facultad de Medicina, Hospital General de México, Universidad Nacional Autónoma de México, México, Distrito Federal, Mexico
Barrón V.:
Univ Nacl Autonoma Mexico, Fac Med, Hosp Gen Mexico, Unidad Med Genom, Mexico City 04510, DF, Mexico
Unidad de Medicina Genómica, Facultad de Medicina, Hospital General de México, Universidad Nacional Autónoma de México, México, Distrito Federal, Mexico
Espinosa A.:
Univ Nacl Autonoma Mexico, Fac Med, Hosp Gen Mexico, Unidad Med Genom, Mexico City 04510, DF, Mexico
Unidad de Medicina Genómica, Facultad de Medicina, Hospital General de México, Universidad Nacional Autónoma de México, México, Distrito Federal, Mexico
Villegas-Sepulveda N.:
Departamento de Biomedicina Molecular, Centro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional, México, Distrito Federal, Mexico
Gómez-Laguna L.:
Univ Nacl Autonoma Mexico, Dept Genet, Fac Med, Hosp Gen Mexico, Mexico City 04510, DF, Mexico
Departamento de Genética, Facultad de Medicina, Hospital General de México, Universidad Nacional Autónoma de México, México, Distrito Federal, Mexico
Nieto-Martínez K.:
Univ Nacl Autonoma Mexico, Dept Genet, Fac Med, Hosp Gen Mexico, Mexico City 04510, DF, Mexico
Departamento de Genética, Facultad de Medicina, Hospital General de México, Universidad Nacional Autónoma de México, México, Distrito Federal, Mexico
Orozco L.:
Laboratorio de Genómica de Enfermedades Complejas, Instituto Nacional de Medicina Genómica, México, Distrito Federal, Mexico
Roman-Basaure E.:
Servicio de Oncología, Hospital General de México, México, Distrito Federal, Mexico
Venegas-Vega C.:
Univ Nacl Autonoma Mexico, Dept Genet, Fac Med, Hosp Gen Mexico, Mexico City 04510, DF, Mexico
Departamento de Genética, Facultad de Medicina, Hospital General de México, Universidad Nacional Autónoma de México, México, Distrito Federal, Mexico
Guardado-Estrada M.:
Univ Nacl Autonoma Mexico, Fac Med, Hosp Gen Mexico, Unidad Med Genom, Mexico City 04510, DF, Mexico
Unidad de Medicina Genómica, Facultad de Medicina, Hospital General de México, Universidad Nacional Autónoma de México, México, Distrito Federal, Mexico
Rangel-López A.:
Unidad de Investigación Médica Enfermedades Nefrológicas, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, México, Distrito Federal, Mexico
Kofman S.:
Univ Nacl Autonoma Mexico, Dept Genet, Fac Med, Hosp Gen Mexico, Mexico City 04510, DF, Mexico
Departamento de Genética, Facultad de Medicina, Hospital General de México, Universidad Nacional Autónoma de México, México, Distrito Federal, Mexico
Berumen J.:
Univ Nacl Autonoma Mexico, Fac Med, Hosp Gen Mexico, Unidad Med Genom, Mexico City 04510, DF, Mexico
Univ Nacl Autonoma Mexico, Dept Expt Med, Fac Med, Mexico City 04510, DF, Mexico
Unidad de Medicina Genómica, Facultad de Medicina, Hospital General de México, Universidad Nacional Autónoma de México, México, Distrito Federal, Mexico
Departamento de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, México, Distrito Federal, Mexico
Servicio de Ginecología, Hospital General de México, México, Distrito Federal, Mexico
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