Polymerized-Type I Collagen Downregulates Inflammation and Improves Clinical Outcomes in Patients with Symptomatic Knee Osteoarthritis Following Arthroscopic Lavage: A Randomize
Por:
Furuzawa-Carballeda J., Lima G., Llorente L., Nunez-Alvarez, C, Ruiz-Ordaz B.H., Echevarría-Zuno S., Hernández-Cuevas V.
Publicada:
1 ene 2012
Resumen:
Objectives. Polymerized-type I collagen (polymerized collagen) is a downmodulator of inflammation and cartilage regenerator biodrug. Aim. To evaluate the effect of intraarticular injections of polymerized collagen after arthroscopic lavage on inflammation and clinical improvement in patients with knee osteoarthritis (OA). Methods. Patients (n = 19) were treated with 6 intraarticular injections of 2 mL of polymerized collagen (n = 10) or 2 mL of placebo (n = 9) during 3 months. Followup was 3 months. The primary endpoints included Lequesne index, pain on a visual analogue scale (VAS), WOMAC, analgesic usage, the number of Tregs and proinflammatory/anti-inflammatory cytokine-expressing peripheral cells. Secondary outcomes were Likert score and drug evaluation. Clinical and immunological improvement was determined if the decrease in pain exceeds 20 mm on a VAS, 20% of clinical outcomes, and inflammatory parameters from baseline. Urinary levels of C-terminal crosslinking telopeptide of col
Filiaciones:
Furuzawa-Carballeda J.:
Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutricin Salvador Zubirán, Vasco de Quiroga No. 15, Col Seccin XVI, 14000 Mexico City, DF, Mexico
Unidad Médica de Alta Especialidad, Hospital de Traumatologa y Ortopedia, IMSS, Boulevard Manuel vila Camacho s/n, Ex-ejido de Oro, 53120 Naucalpan, MEX, Mexico
Lima G.:
Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutricin Salvador Zubirán, Vasco de Quiroga No. 15, Col Seccin XVI, 14000 Mexico City, DF, Mexico
Llorente L.:
Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutricin Salvador Zubirán, Vasco de Quiroga No. 15, Col Seccin XVI, 14000 Mexico City, DF, Mexico
Ruiz-Ordaz B.H.:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Mol Biol & Biotechnol, Mexico City 04510, DF, Mexico
Echevarría-Zuno S.:
Unidad Médica de Alta Especialidad, Hospital de Traumatologa y Ortopedia, IMSS, Boulevard Manuel vila Camacho s/n, Ex-ejido de Oro, 53120 Naucalpan, MEX, Mexico
Hernández-Cuevas V.:
Unidad Médica de Alta Especialidad, Hospital de Traumatologa y Ortopedia, IMSS, Boulevard Manuel vila Camacho s/n, Ex-ejido de Oro, 53120 Naucalpan, MEX, Mexico
All Open Access, Gold
|