Development of Protective Autoimmunity by Immunization with a Neural-Derived Peptide Is Ineffective in Severe Spinal Cord Injury
Por:
Martinon, S, García E., Gutierrez-Ospina G., Mestre H., Ibarra A.
Publicada:
14 feb 2012
Resumen:
Protective autoimmunity (PA) is a physiological response to central nervous system trauma that has demonstrated to promote neuroprotection after spinal cord injury (SCI). To reach its beneficial effect, PA should be boosted by immunizing with neural constituents or neural-derived peptides such as A91. Immunizing with A91 has shown to promote neuroprotection after SCI and its use has proven to be feasible in a clinical setting. The broad applications of neural-derived peptides make it important to determine the main features of this anti-A91 response. For this purpose, adult Sprague-Dawley rats were subjected to a spinal cord contusion (SCC; moderate or severe) or a spinal cord transection (SCT; complete or incomplete). Immediately after injury, animals were immunized with PBS or A91. Motor recovery, T cell-specific response against A91 and the levels of IL-4, IFN-gamma and brain-derived neurotrophic factor (BDNF) released by A91-specific T (T-A91) cells were evaluated. Rats with modera
Filiaciones:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Biol Celular & Fisiol, Mexico City 04510, DF, Mexico
Centro de Investigación del Proyecto CAMINA A.C, Mexico City, Mexico
Facultad de Ciencias de la Salud, Universidad Anáhuac México Norte, Huixquilucan, Estado De México, Mexico
All Open Access, Gold
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