RXR alpha deletion and E6E7 oncogene expression are sufficient to induce cervical malignant lesions in vivo
Por:
Ocadiz-Delgado R., Castaneda-Saucedo, E, Indra A.K., Hernandez-Pando R., Flores-Guizar P., Cruz-Colin J.L., Recillas-Targa F., Perez-Ishiwara G., Covarrubias L., Gariglio P.
Publicada:
28 abr 2012
Resumen:
Cervical cancer is the second leading cause of cancer deaths among women worldwide. High-Risk-Human Papillomaviruses (HR-HPVs) play an important etiologic role in the development of carcinoma of the uterine cervix. However, host factors are important in determining the outcome of genital HPV infection as most cervical precancerous lesions containing HR-HPVs do not progress to invasive carcinomas. Retinoids, acting through nuclear receptors (RARs, RXRs), play a crucial role in cervix development and homeostasis regulating growth and differentiation of a wide variety of cell types; indeed, they can inhibit cell proliferation, and induce cell differentiation or apoptotic cell death. Here we introduce a mouse model that develops spontaneously malignant cervical lesions allowing the study of the cooperative effect between HPV16E6E7 expression and the lack of RXR alpha in cervical cancer development. This model could be useful to study multistep carcinogenesis of uterine cervix tissue and mi
Filiaciones:
Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Dept Mol Genet, Mexico City 04510, DF, Mexico
Univ Nacl Autonoma Mexico, Inst Biotechnol, Dept Mol Genet, Mexico City 04510, DF, Mexico
Dept. of Genetics and Molecular Biology, Centro de Investigacion y de Estudios Avanzados del IPN (CINVESTAV-IPN), Av. IPN 2508, Col. San Pedro Zacatenco, 07360. Mexico, DF, Mexico
PIBioM, Escuela Nacional de Medicina y Homeopatia-IPN, Guillermo Massieu Helguera, 239 Fracc. La Escalera-Ticoman, Mexico, DF, Mexico
Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Centre National de la Recherche Scientifique (CNRS), Inst. National de la Santé et de la Recherche Medicale (INSERM), Universite Louis Pasteur, Illkirch-Cedex, Strasbourg, France
Department of Dermatology, Oregon Health and Science University, Portland, OR 97239, United States
Dept. of Pathology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran (INCMNSZ), Vasco de Quiroga 15, Col. Seccion XVI, Tlalpan, 14000. Mexico, D.F., Mexico
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