Genetic variants associated with severe pneumonia in A/H1N1 influenza infection
Por:
Zuniga, J, Buendía-Roldán I., Zhao Y., Jiménez L., Torres D., Romo J., Ramírez G., Cruz A., Vargas-Alarcon G., Sheu, CC, Chen F., Su L., Tager A.M., Pardo A., Selman M., Christiani D.C.
Publicada:
1 mar 2012
Resumen:
The A/H1N1 influenza strain isolated in Mexico in 2009 caused severe pulmonary illness in a small number of exposed individuals. Our objective was to determine the influence of genetic factors on their susceptibility. We carried out a case-control association study genotyping 91 patients with confirmed severe pneumonia from A/H1N1 infection and 98 exposed but asymptomatic household contacts, using the HumanCVD BeadChip (Illumina, San Diego, CA, USA). Four risk single-nucleotide polymorphisms were significantly (p < 0.0001) associated with severe pneumonia: rs1801274 (Fc fragment of immunoglobulin G, low-affinity IIA, receptor (FCGR2A) gene, chromosome 1; OR 2.68, 95% CI 1.69-4.25); rs9856661 (gene unknown, chromosome 3; OR 2.62, 95% CI 1.64-4.18); rs8070740 (RPA interacting protein (RPAIN) gene, chromosome 17; OR 2.67, 95% CI 1.63-4.39); and rs3786054 (complement component 1, q subcomponent binding protein (C1QBP) gene, chromosome 17; OR 3.13, 95% CI 1.89-5.17). All SNP associations re
Filiaciones:
Univ Nacl Autonoma Mexico, Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Mexico City 04510, DF, Mexico
Univ Nacl Autonoma Mexico, Inst Nacl Cardiol, Mexico City 04510, DF, Mexico
Univ Nacl Autonoma Mexico, Fac Ciencias, Mexico City 04510, DF, Mexico
Dept. of Environmental Health, Harvard School of Public Health, Massachusetts General Hospital, Boston, MA, United States
Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States
Dept. of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States
All Open Access, Bronze
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