Antidepressant-like effects of an alkaloid extract of the aerial parts of Annona cherimolia in mice
Por:
Martinez-Vazquez, M, Estrada-Reyes, R, Escalona, AGA, Velazquez, IL, Martinez-Mota, L, Moreno, J, Heinze, G
Publicada:
6 ene 2012
Resumen:
Ethnopharmacological relevance: Several species of Annona (Annonaceae) are used in traditional Mexican medicine by their anti-anxiety, anticonvulsant and tranquilizing properties. It has been reported that the alkaloids isolated from some species of the Annona have affinity to serotonergic 5-HT1A receptors and modulate dopaminergic transmission, which is involved in depressive disorders. Aim of the study: To investigate the antidepressant-like effect of an alkaloid extract from the aerial parts of Annona cherimola (TA) in mice. Materials and methods: The antidepressant-like effect was evaluated in the forced swimming test. To elucidate a possible mechanism of action, experiments of synergism with antidepressant drugs, such as imipramine (IMI), clomipramine (CLIMI), and fluoxetine (FLX), were carried out. The neurotransmitter content (DA: dopamine, 5HT: serotonin and its metabolites, HVA: homovanillic acid and 5HIAA: 5-hydroxyindoleacetic) in the whole brain of mice were also determined
Filiaciones:
Martinez-Vazquez, M:
Univ Nacl Autonoma Mexico, Inst Quim, Mexico City 04510, DF, Mexico
Heinze, G:
Univ Nacl Autonoma Mexico, Dept Psiquiatria & Salud Mental, Fac Med, Mexico City 04510, DF, Mexico
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