Th2-Associated Alternative Kupffer Cell Activation Promotes Liver Fibrosis without Inducing Local Inflammation
Por:
López-Navarrete G., Ramos-Martínez E., Suárez-Álvarez K., Aguirre-García J., Ledezma-Soto Y., León-Cabrera S., Gudino-Zayas, M, Guzmán C., Gutiér-rez-Reyes G., Hernández-Ruíz J., Camacho-Arroyo I., Robles-Díaz G., Kershenobich D., Terrazas L.I., Escobedo G.
Publicada:
1 ene 2011
Resumen:
Cirrhosis is the final outcome of liver fibrosis. Kupffer cell-mediated hepatic inflammation is considered to aggravate liver injury and fibrosis. Alternatively-activated macrophages are able to control chronic inflammatory events and trigger wound healing processes. Nevertheless, the role of alternative Kupffer cell activation in liver harm is largely unclear. Thus, we evaluated the participation of alternatively-activated Kupffer cells during liver inflammation and fibrosis in the murine model of carbon tetrachloride-induced hepatic damage. To stimulate alternative activation in Kupffer cells, 20 Taenia crassiceps (Tc) larvae were inoculated into BALBc/AnN female mice. Six weeks post-inoculation, carbon tetrachloride or olive oil were orally administered to Tc-inoculated and non-inoculated mice twice per week during other six weeks. The initial exposure of animals to T. crassiceps resulted in high serum concentrations of IL-4 accompanied by a significant increase in the hepatic mRNA
Filiaciones:
López-Navarrete G.:
Unidad de Medicina Experimental, Hospital General de México, Dr. Balmis #148, Col. Doc-tores, C.P. 06726, México D.F., Mexico
Ramos-Martínez E.:
Univ Nacl Autonoma Mexico, Hosp Gen Mexico, Fac Med, Dept Expt Med, Mexico City 06726, DF, Mexico
Suárez-Álvarez K.:
Unidad de Medicina Experimental, Hospital General de México, Dr. Balmis #148, Col. Doc-tores, C.P. 06726, México D.F., Mexico
Aguirre-García J.:
Univ Nacl Autonoma Mexico, Hosp Gen Mexico, Fac Med, Unidad Patol, Mexico City 06726, DF, Mexico
Ledezma-Soto Y.:
Univ Nacl Autonoma Mexico, Fac Estudios Super Iztacala, Unidad Biomed, Mexico City 54090, Estado De Mexic, Mexico
León-Cabrera S.:
Univ Nacl Autonoma Mexico, Fac Med, Dept Microbiol & Parasitol, Mexico City 04510, DF, Mexico
Gudino-Zayas, M:
Univ Nacl Autonoma Mexico, Hosp Gen Mexico, Fac Med, Dept Expt Med, Mexico City 06726, DF, Mexico
Guzmán C.:
Unidad de Medicina Experimental, Hospital General de México, Dr. Balmis #148, Col. Doc-tores, C.P. 06726, México D.F., Mexico
Gutiér-rez-Reyes G.:
Univ Nacl Autonoma Mexico, Hosp Gen Mexico, Fac Med, Dept Expt Med, Mexico City 06726, DF, Mexico
Hernández-Ruíz J.:
Unidad de Medicina Experimental, Hospital General de México, Dr. Balmis #148, Col. Doc-tores, C.P. 06726, México D.F., Mexico
Camacho-Arroyo I.:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Biol, Mexico City 04510, DF, Mexico
Robles-Díaz G.:
Univ Nacl Autonoma Mexico, Hosp Gen Mexico, Fac Med, Dept Expt Med, Mexico City 06726, DF, Mexico
Kershenobich D.:
Univ Nacl Autonoma Mexico, Hosp Gen Mexico, Fac Med, Dept Expt Med, Mexico City 06726, DF, Mexico
Terrazas L.I.:
Univ Nacl Autonoma Mexico, Fac Estudios Super Iztacala, Unidad Biomed, Mexico City 54090, Estado De Mexic, Mexico
Escobedo G.:
Unidad de Medicina Experimental, Hospital General de México, Dr. Balmis #148, Col. Doc-tores, C.P. 06726, México D.F., Mexico
Gold
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