Impact of Metabolic Syndrome on Biochemical Recurrence of Prostate Cancer after Radical Prostatectomy
Por:
Castillejos-Molina R., Rodríguez-Covarrubias F., Sotomayor M., Gómez-Alvarado M.O., Villalobos-Gollás M., Gabilondo F., Feria-Bernal G.
Publicada:
1 ene 2011
Categoría:
Urology
Resumen:
Introduction: Metabolic syndrome (MS) is linked to hormone-dependent cancers. Its prognostic implication in prostate cancer (PCa) is unclear. We analyzed the impact of MS in the survival of men with PCa treated surgically. Patients and Methods: We studied patients with PCa, treated surgically between 1990 and 2007, and compared the survival of men with MS (group 1) and without MS (group 2). A subgroup analysis of those in stage pT2 was also performed. We calculated biochemical progression-free survival (bPFS) and cancer-specific survival, and the relation of clinical and pathological variables with these end-points. Results: 65 men had MS. The 5- and 10-year bPFS in group 1 was 36 and 32% vs. 72 and 68% in group 2 (p < 0.0001). In multivariate analysis, prostate-specific antigen (p = 0.001) and MS (p < 0.0001) predicted biochemical progression/recurrence (BP/R). There was no difference in cancer-specific survival between groups (p = 0.40). Of 146 men in stage pT2, 38 had MS; group 1 me
Filiaciones:
Castillejos-Molina R.:
Department of Urology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Colonia Sección XVI, Vasco de Quiroga 15, Mexico City, Tlalpan C.P. 14000, Mexico D.F., Mexico
Rodríguez-Covarrubias F.:
Department of Urology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Colonia Sección XVI, Vasco de Quiroga 15, Mexico City, Tlalpan C.P. 14000, Mexico D.F., Mexico
Sotomayor M.:
Department of Urology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Colonia Sección XVI, Vasco de Quiroga 15, Mexico City, Tlalpan C.P. 14000, Mexico D.F., Mexico
Gómez-Alvarado M.O.:
Department of Urology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Colonia Sección XVI, Vasco de Quiroga 15, Mexico City, Tlalpan C.P. 14000, Mexico D.F., Mexico
Villalobos-Gollás M.:
Department of Urology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Colonia Sección XVI, Vasco de Quiroga 15, Mexico City, Tlalpan C.P. 14000, Mexico D.F., Mexico
Gabilondo F.:
Department of Urology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Colonia Sección XVI, Vasco de Quiroga 15, Mexico City, Tlalpan C.P. 14000, Mexico D.F., Mexico
Feria-Bernal G.:
Department of Urology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Colonia Sección XVI, Vasco de Quiroga 15, Mexico City, Tlalpan C.P. 14000, Mexico D.F., Mexico
|