Dopaminergic Modulation of the Striatal Microcircuit: Receptor-Specific Configuration of Cell Assemblies
Por:
Carrillo-Reid, L, Hernandez-Lopez, S, Tapia, D, Galarraga, E, Bargas, J
Publicada:
19 oct 2011
Categoría:
Neuroscience (miscellaneous)
Resumen:
Selection and inhibition of motor behaviors are related to the coordinated activity and compositional capabilities of striatal cell assemblies. Striatal network activity represents a main step in basal ganglia processing. The dopaminergic system differentially regulates distinct populations of striatal medium spiny neurons (MSNs) through the activation of D(1)- or D(2)-type receptors. Although postsynaptic and presynaptic actions of these receptors are clearly different in MSNs during cell-focused studies, their activation during network activity has shown inconsistent responses. Therefore, using electrophysiological techniques, functional multicell calcium imaging, and neuronal population analysis in rat corticostriatal slices, we describe the effect of selective dopaminergic receptor activation in the striatal network by observing cell assembly configurations. At the microcircuit level, during striatal network activity, the selective activation of either D(1)- or D(2)-type receptors
Filiaciones:
Carrillo-Reid, L:
Univ Nacl Autonoma Mexico, Inst Cellular Physiol, Div Neurosci, Fac Med, Mexico City 04510, DF, Mexico
Hernandez-Lopez, S:
Univ Nacl Autonoma Mexico, Fac Med, Dept Physiol, Mexico City 04510, DF, Mexico
Tapia, D:
Univ Nacl Autonoma Mexico, Inst Cellular Physiol, Div Neurosci, Fac Med, Mexico City 04510, DF, Mexico
Galarraga, E:
Univ Nacl Autonoma Mexico, Inst Cellular Physiol, Div Neurosci, Fac Med, Mexico City 04510, DF, Mexico
Bargas, J:
Univ Nacl Autonoma Mexico, Inst Cellular Physiol, Div Neurosci, Fac Med, Mexico City 04510, DF, Mexico
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