Antimicrobial Activity and Cytotoxic Effects of Magnolia dealbata and its Active Compounds
Por:
Jacobo-Salcedo, MD, Gonzalez-Espindola L.A., Alonso-Castro A.J., Gonzalez-Martinez, MD, Domínguez F., Garcia-Carranca A.
Publicada:
1 ago 2011
Resumen:
Multi-drug resistance is of great concern for public health worldwide and necessitates the search for new antimicrobials from sources such as plants. Several Magnolia (Magnoliaceae) species have been reported to exert antimicrobial effects on sensitive and multidrug-resistant microorganisms. However, the antimicrobial properties of Magnolia dealbata have not been experimentally evaluated. The antimicrobial effects of an ethanol extract of Magnolia dealbata seeds (MDE) and its active compounds honokiol (HK) and magnolol (MG) were tested against the phytopathogen Clavibacter michiganensis subsp. michiganensis and several human multi-drug resistant pathogens using the disk-diffusion assay. The effects of MDE and its active compounds on the viability of human peripheral blood mononuclear cells (PBMC) were evaluated using MTT assay. MDE and its active compounds had antimicrobial activity (inhibition zone > 10 mm) against C. michiganensis, Pseudomonas aeruginosa, Acinetobacter baumannii, Aci
Filiaciones:
Gonzalez-Espindola L.A.:
Facultad de Ciencias Químicas, Universidad Juárez del Estado de Durango, Avenida Articulo 123, Fraccionamiento Filadelfia, Gómez Palacio, Durango, 35010, Mexico
Alonso-Castro A.J.:
Univ Nacl Autonoma Mexico, Fac Quim, Mexico City 04510, DF, Mexico
Domínguez F.:
Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social (IMSS), Km. 4.5, Carretera Federal Atlixco-Metepec, 74360 Metepec, Puebla, Mexico
Garcia-Carranca A.:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mexico City 04510, DF, Mexico
All Open Access; Bronze
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