Controlled release of IFC-305 encapsulated in silica nanoparticles for liver cancer synthesized by sol-gel
Por:
Albarran L., López T., Quintana P., Chagoya V.
Publicada:
5 jul 2011
Categoría:
Colloid and Surface Chemistry
Resumen:
IFC-305 was encapsulated into nanostructured silica and functionalized with OH groups by the sol-gel process using tetraethoxysilane (TEOS), to be used for a drug delivery system for the treatment of liver cancer. Synthesis was carried out at different molar hydrolysis ratios: 4, 8, 16 and 24 mol of water and drug concentrations of 10, 20 and 30%. Characterization of IFC-silica reservoirs by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), thermal analysis (DTA-TGA), transmission electron microscopy (TEM), and N(2) adsorption-desorption isotherms (BET), confirms that IFC-305 was trapped and stabilized in the SiO(2)-OH matrix. Drug release was determined by UV spectrophotometry over a period of 1000 h. Results showed that the morphology and specific surface area are controlled by the amount of loaded drug and water content for the different synthesized reservoir systems. However, the in vitro analysis of drug discharge showed that the rate of drug release was ind
Filiaciones:
Univ Nacl Autonoma Mexico, Dept Biol Celular, Inst Fisiol Celular, Mexico City 04510, DF, Mexico
Universidad Autónoma Metropolitana-Xochimilco, Calzada del Hueso 1100, Col. Villa Quietud, Coyoacán, C.P. 04960, D.F. México, Mexico
National Neurology and Neurosurgery Institute Nanotechnology for Medicine Laboratory, Av. Insurgentes Sur 3877, Col. La Fama, Tlalpan, 14269, D.F. México, Mexico
Departmento de Física Aplicada, CINVESTAV-IPN, Unidad Mérida, A.P. 73, Cordemex, C.P. 97310, Mérida, Yucatán, Mexico
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