Detection of Cytotoxic Activity of Lectin on Human Colon Adenocarcinoma (Sw480) and Epithelial Cervical Carcinoma (C33-A)
Por:
Valadez-Vega C., Alvarez-Manilla G., Riverón-Negrete L., García-Carrancá A., Morales-González J.A., Zuniga-Pérez C., Madrigal-Santillán E., Esquivel-Soto J., Esquivel-Chirino C., Villagómez-Ibarra R., Bautista M., Morales-González A.
Publicada:
1 mar 2011
Resumen:
Lectins comprise a heterogeneous class of proteins that recognize the carbohydrate moieties of glycoconjugates with high specificity. Numerous studies have shown that lectins are capable of recognizing specific carbohydrate moieties displayed by malignant cells or tissues. The present work was performed to investigate the effects of tepary bean (Phaseolus acutifolius) lectins on proliferation, colony formation, and alteration of DNA synthesis of human malignant cells. Tepary bean lectin showed dose dependent effects on the inhibition of viability as well as on colony formation in two human malignant cells lines (C33-A, Sw480); By contrast, tepary bean lectin only showed significant effects on DNA synthesis on Sw480 cells. Our results provide evidence of the anti- proliferative and cytotoxic effects of the tepary bean lectins on C33-A and Sw480 cells lines.
Filiaciones:
Valadez-Vega C.:
Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Ex-Hacienda de la Concepción, Tilcuautla, 42080 Pachuca de Soto, Hgo, Mexico
Alvarez-Manilla G.:
Ezose Sciences Inc, Pine Brook, NJ 07058, United States
Riverón-Negrete L.:
Parasitología Experimental, Instituto Nacional de Pediatría, Mexico, D.F., Mexico
García-Carrancá A.:
Univ Nacl Autonoma Mexico, Lab Virus & Canc, Unidad Invest Biomed Canc, Inst Invest Biomed, Mexico City 04510, DF, Mexico
Morales-González J.A.:
Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Ex-Hacienda de la Concepción, Tilcuautla, 42080 Pachuca de Soto, Hgo, Mexico
Zuniga-Pérez C.:
Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Ex-Hacienda de la Concepción, Tilcuautla, 42080 Pachuca de Soto, Hgo, Mexico
Madrigal-Santillán E.:
Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Ex-Hacienda de la Concepción, Tilcuautla, 42080 Pachuca de Soto, Hgo, Mexico
Esquivel-Soto J.:
Univ Nacl Autonoma Mexico, Fac Odontol, Mexico City 04510, DF, Mexico
Esquivel-Chirino C.:
Univ Nacl Autonoma Mexico, Fac Odontol, Mexico City 04510, DF, Mexico
Villagómez-Ibarra R.:
Instituto de Ciencias Básicas e Ingeniería, Universidad Autónoma del Estado de Hidalgo, Pachuca, Hidalgo, Mexico
Bautista M.:
Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Ex-Hacienda de la Concepción, Tilcuautla, 42080 Pachuca de Soto, Hgo, Mexico
Morales-González A.:
Escuela Superior de Cómputo, Instituto Politécnico Nacional, México, D.F., Mexico
All Open Access, Gold
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