Controlled release of phenytoin for epilepsy treatment from titania and silica based materials
Por:
López T., Ortiz E., Meza D., Basaldella E., Bokhimi X., Magana, C, Sepúlveda A., Rodríguez F., Ruiz J.
Publicada:
15 abr 2011
Resumen:
Template technique was used to obtain well ordered nanostructured materials: mesoporous silica and nanostructured titania tubes. This technique permits the synthesis of solids with controlled mesoporosity, where a large variety of molecules that have therapeutic activity can be hosted and further released to specific sites. In this work phenytoin (PH), a drug used in epilepsy treatment, was loaded in ordered mesoporous silica (SBA 15) and nanostructured titania tubes (TiO(2)). The pure materials and those containing PH were characterized by X-ray diffraction, FTIR spectroscopy, transmission electron microscopy (TEM), scanning electron microscopy (SEM) and N(2) adsorption-desorption at 77 K. In order to determine the loading capacity of the antiepileptic drug on these silica- and titania-based materials, the loading and release of PH was investigated using UV-vis spectroscopy. Tubular structures were found for the titania samples, for which the X-ray diffractograms showed to be formed b
Filiaciones:
Univ Nacl Autonoma Mexico, Inst Fis, Mexico City 01000, DF, Mexico
Universidad Autónoma Metropolitana-Xochimilco, Departamento de Microbiología, Calzada del Hueso 1100, Col. Villa Quietud, Coyoacan, C.P. 04960, Mexico D.F., Mexico
Instituto Nacional de Neurología y Neurocirugía MVS, Laboratorio de Nanotecnología, Av. Insurgentes Sur 3877, Col. La Fama, Tlalpan, 14269, México, D.F., Mexico
Department of Chemical and Biomolecular Engineering, Tulane University, New Orleans, LA 70118, United States
Universidad Autónoma Metropolitana-Iztapalapa, Departamento de Química, Av. San Rafael Atlixco 186, Mexico D.F., C.P. 09340, Mexico
CIC-CINDECA, Universidad Nacional de la Plata, Calle 47 No 257, La Plata, Argentina
Departamento de Química Inorgánica, Universidad de Alicante, Apartado 99, E-03080 Alicante, Spain
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