Treatment of Parkinson's disease: nanostructured sol-gel silica-dopamine reservoirs for controlled drug release in the central nervous system
Por:
López T., Bata-García J.L., Esquivel D., Ortiz-Islas E., Gonzalez R., Ascencio J., Quintana P., Oskam G., Álvarez-Cervera F.J., Heredia-López F.J., Góngora-Alfaro J.L.
Publicada:
1 ene 2011
Resumen:
Introduction: We have evaluated the use of silica-dopamine reservoirs synthesized by the-sol-gel approach with the aim of using them in the treatment of Parkinson's disease, specifically as a device for the controlled release of dopamine in the striatum. Theoretical calculations illustrate that dopamine is expected to assume a planar structure and exhibit weak interactions with the silica surface. Methods: Several samples were prepared by varying the wt% of dopamine added during the hydrolysis of tetraethyl orthosilicate. The silica-dopamine reservoirs were characterized by N-2 adsorption, scanning and transmission electron microscopy, and Fourier transform infrared spectroscopy. The in vitro release profiles were determined using ultraviolet visible absorbance spectroscopy. The textural analyses showed a maximum value for the surface area of 620 m(2)/g nanostructured silica materials. The stability of dopamine in the silica network was confirmed by infrared and C-13-nuclear magnetic r
Filiaciones:
UNAM, Inst Ciencias Fis, Cuernavaca, Morelos, Mexico
Departamento de Atención a la Salud, UAM-Xochimilco, Calzada del Hueso, Coyoacán, Mexico
Laboratorio de Nanotecnología, Instituto Nacional de Neurología y Neurocirugía MVS, Tlalpan, Mexico
Departamento de Química e Ingeniería Biomolecular, Universidad de Tulane, New Orleans, United States
Departamento de Neurociencias, Centro de Investigaciones Regionales Dr Hideyo Noguchi, Universidad Autónoma de Yucatán, Mérida, Yucatán, Mexico
Universidad de Guanajuato, Centro de Investigaciones en Química Inorgánica, Noria Alta Guanajuato, Mexico
Departamento de Física Aplicada, CINVESTAV-IPN, Mérida, Yucatán, Mexico
All Open Access, Gold
|