Comparison of Ca2+ Currents of Chromaffin Cells from Normotensive Wistar Kyoto and Spontaneously Hypertensive Rats
Por:
Segura-Chama P., Hernández A., Jiménez-Pérez N., Alejandre-García T., Rivera-Cerecedo C.V., Hernández-Guijo J., Hernández-Cruz A.
Publicada:
1 nov 2010
Resumen:
Spontaneously hypertensive rats (SHR) are widely used as model to investigate the pathophysiological mechanisms of essential hypertension. Catecholamine plasma levels are elevated in SHR, suggesting alterations of the sympathoadrenal axis. The residual hypertension in sympathectomized SHR is reduced after demedullation, suggesting a dysfunction of the adrenal medulla. Intact adrenal glands exposed to acetylcholine or high K release more catecholamine in SHR than in normotensive Wistar Kyoto (WKY) rats, and adrenal chromaffin cells (CCs) from SHR secrete more catecholamines than CCs from WKY rats. Since Ca2+ entry through voltage-gated Ca2+ channels (VGCC) triggers exocytosis, alterations in the functional properties of these channels might underlie the enhanced catecholamine release in SHR. This study compares the electrophysiological properties of VGCC from CCs in acute adrenal slices from WKY rats and SHR at an early stage of hypertension. No significant differences were found in the
Filiaciones:
Segura-Chama P.:
Univ Nacl Autonoma Mexico, Div Neurociencias, Dept Neurociencia Cognit, Inst Fisiol Celular, Mexico City 04510, DF, Mexico
Hernández A.:
Univ Nacl Autonoma Mexico, Div Neurociencias, Dept Neurociencia Cognit, Inst Fisiol Celular, Mexico City 04510, DF, Mexico
Jiménez-Pérez N.:
Univ Nacl Autonoma Mexico, Div Neurociencias, Dept Neurociencia Cognit, Inst Fisiol Celular, Mexico City 04510, DF, Mexico
Alejandre-García T.:
Univ Nacl Autonoma Mexico, Div Neurociencias, Dept Neurociencia Cognit, Inst Fisiol Celular, Mexico City 04510, DF, Mexico
Rivera-Cerecedo C.V.:
Univ Nacl Autonoma Mexico, Unidad Acad Bioterio, Inst Fisiol Celular, Mexico City 04510, DF, Mexico
Hernández-Guijo J.:
Departamento de Farmacología y TerapéUtica, Facultad de Medicina, Universidad Autónoma de Madrid, Av. Arzobispo Morcillo 4, Madrid 28029, Spain
Hernández-Cruz A.:
Univ Nacl Autonoma Mexico, Div Neurociencias, Dept Neurociencia Cognit, Inst Fisiol Celular, Mexico City 04510, DF, Mexico
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