Study of the stabilization of zinc phthalocyanine in sol-gel TiO2 for photodynamic therapy applications
Por:
Lopez T., Ortiz E., Alvarez M., Navarrete J., Odriozola J.A., Martinez-Ortega F., Páez-Mozo E.A., Escobar P., Espinoza K.A., Rivero I.A.
Publicada:
1 dic 2010
Resumen:
Photodynamic therapy (PDT) has emerged as an alternative and promising noninvasive treatment for cancer. It is a two-step procedure that uses a combination of molecular oxygen, visible light, and photosensitizer (PS) agents; phthalocyanine (Pc) was supported over titanium oxide but has not yet been used for cell inactivation. Zinc phthalocyanine (ZnPc) molecules were incorporated into the porous network of titanium dioxide (TiO2) using the sol-gel method. It was prepared from stock solutions of ZnPc and TiO2. ZnPc-TiO2 was tested with four cancer cell lines. The characterization of supported ZnPc showed that phthalocyanine is linked by the N-pyrrole to the support and is stable up to 250 degrees C, leading to testing for PDT. The preferential localization in target organelles such as mitochondria or lysosomes could determine the cell death mechanism after PDT. The results suggest that nanoparticulated TiO2 sensitized with ZnPc is an excellent candidate as sensitizer in PDT against canc
Filiaciones:
Universidad Autónoma Metropolitana, Departamento de Atención a la Salud, DF, Mexico
Instituto Nacional de Neurología Y Neurocirugía MVS, Laboratorio de Nanotecnología, Tlalpan, DF, Mexico
Department of Chemical and Biomolecules Engineering, Tulane University, New Orleans, Louisiana, United States
Instituto Mexicano del Petróleo, DF, Mexico
Instituto de Materiales de Sevilla, Centro Mixto CSIC-US, Isla de la Cartuja, Sevilla, Spain
Centro de investigacion de catalisis CICAT, Depto de Quimica, Universidad Industrial de Santander, Bucaramanga, Colombia
Centro de Investigación en Enfermedades Tropicales CINTROP, Escuela de Medicina, Universidad Industrial de Santander, Bucaramanga, Colombia
Centro de Graduados e Investigación, Instituto Tecnológico de Tijuana, Tijuana, DF, Mexico
Instituto Nacional de Investigaciones Nucleares, Departamento de Química, Ocoyoacac, DF, Mexico
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