Long-term follow-up of patients with type 1 diabetes transplanted with neonatal pig islets
Por:
Valdes-Gonzalez R., Rodriguez-Ventura A.L., White, DJG, Bracho-Blanchet E., Castillo A., Ramírez-González B., López-Santos M.G., León-Mancilla B.H., Dorantes L.M.
Publicada:
1 dic 2010
Resumen:
P>Pancreas transplantation is an option to achieve better metabolic control and decrease chronic complications in patients with diabetes. Xenotransplantation becomes an important alternative. In this study, we show the clinical outcome of patients with type 1 diabetes transplanted with neonatal pig islets without immunosuppression. In a longitudinal study of 23 patients with type 1 diabetes, who received porcine islets between 2000 and 2004, we registered demographic and clinical characteristics every 3 months and chronic complications evaluation yearly. Porcine C-peptide was measured in urine samples under basal conditions and after stimulation with l-arginine. More than 50% were female, median current age was 20 center dot 8 years, median diabetes duration at transplantation 5 center dot 5 years, median current diabetes duration 11 years and median time post-transplantation 5 center dot 7 years. Their media of glycosylated haemoglobin reduced significantly after the first transplanta
Filiaciones:
Valdes-Gonzalez R.:
Univ Nacl Autonoma Mexico, Dept Cirugia, Fac Med, Mexico City 04510, DF, Mexico
Rodriguez-Ventura A.L.:
Laboratorio de Terapia Celular, Hospital General de México, Mexico City, Mexico
Bracho-Blanchet E.:
Departamento de Cirugía, Hospital Infantil de México 'Federico Gómez', Hospital General de México, Mexico City, Mexico
Castillo A.:
Departamento de Endocrinología, Hospital General de México, México City, Mexico
Ramírez-González B.:
Laboratorio de Terapia Celular, Hospital General de México, Mexico City, Mexico
López-Santos M.G.:
Laboratorio de Terapia Celular, Hospital General de México, Mexico City, Mexico
León-Mancilla B.H.:
Univ Nacl Autonoma Mexico, Dept Cirugia, Fac Med, Mexico City 04510, DF, Mexico
Dorantes L.M.:
Laboratorio de Terapia Celular, Hospital General de México, Mexico City, Mexico
All Open Access; Green
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