Glycine regulates inflammatory markers modifying the energetic balance through PPAR and UCP-2
Por:
Almanza-Perez J.C., Alarcon-Aguilar F.J., Blancas-Flores G., Campos-Sepulveda A.E., Roman-Ramos R., Garcia-Macedo R., Cruz M.
Publicada:
1 oct 2010
Categoría:
Pharmacology
Resumen:
Obesity is widely recognized as cause of metabolic syndrome and cardiovascular disease. It is provoked by imbalance between the spending and consumption of energy associated with a chronic inflammatory condition due to excessive storage of fat tissue. Obese patients have an impaired inflammatory profile that contributes to the development of vascular complications, with fat tissue being partially responsible for controlling both processes: energy balance (through PPAR) and inflammatory condition (through inflammatory markers). White adipose tissue produces cytokines (IL-6, INF-alpha, resistin, adiponectin, etc.) and participates in a broad spectrum of processes. Recently, glycine has been reported to have anti-inflammatory properties which reduce TNF-alpha and IL-6 levels and increase adiponectin in 3T3-L1 adipocytes and in fat tissue of obese mice. In this study, the possible regulatory role of glycine on some factors involved in storage and energy burning (PPAR-gamma, PPAR-alpha, PPA
Filiaciones:
Almanza-Perez J.C.:
Posgrado en Biologia Experimental, Division de Ciencias Biologicas y de la Salud, Universidad Autonoma Metropolitana Unidad Iztapalapa, Apdo- Postal 55-535, CP 09340, DF Mex, Mexico
Alarcon-Aguilar F.J.:
Laboratorio de Farmacologia, Departamento de Ciencias de la Salud, Division de Ciencias Biologicas y de la Salud, Universidad Autonoma Metropolitana, Unidad Iztapalapa, Apdo- Postal 55-535, CP 09340, DF Mex, Mexico
Blancas-Flores G.:
Unidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, CMNSXXI, Instituto Mexicano del Seguro Social, DF Mex, Mexico
Campos-Sepulveda A.E.:
Univ Nacl Autonoma Mexico, Lab Toxicol, Dept Farmacol, Fac Med, Mexico City 04510, DF, Mexico
Roman-Ramos R.:
Laboratorio de Farmacologia, Departamento de Ciencias de la Salud, Division de Ciencias Biologicas y de la Salud, Universidad Autonoma Metropolitana, Unidad Iztapalapa, Apdo- Postal 55-535, CP 09340, DF Mex, Mexico
Garcia-Macedo R.:
Unidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, CMNSXXI, Instituto Mexicano del Seguro Social, DF Mex, Mexico
Cruz M.:
Unidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, CMNSXXI, Instituto Mexicano del Seguro Social, DF Mex, Mexico
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