Interleukin 1 receptor antagonist polymorphisms are associated with the risk of developing acute coronary syndrome in Mexicans
Por:
Fragoso J.M., Delgadillo H., Llorente L., Chuquiure E., Juárez-Cedillo T., Vallejo M., Lima G., Furuzawa-Carballeda J., Pena-Duque, MA, Martínez-Ríos M.A., Vargas-Alarcón G.
Publicada:
30 oct 2010
Resumen:
Inflammation plays an essential role in the development and progression of atherosclerotic lesions. Cytokines of the interleukin-1 family are central regulators in immunoinflammatory mechanisms. In the present work, the role of interleukin 1 (IL-1) and IL-1 receptor antagonist (IL-1 RN) gene polymorphisms as susceptibility markers for acute coronary syndrome (ACS) was evaluated. Six polymorphisms in the IL-1 gene cluster members were genotyped by 5' exonuclease TaqMan genotyping assays in 289 ACS patients and 248 healthy controls. Haplotypes were constructed after linkage disequilibrium analysis. Statistically significant associations were found between three polymorphisms of the IL-IRA gene (rs419598, rs315951, and rs2234663) and the development ACS. The polymorphism RN.47C (rs419598) was associated with hypertension, previous myocardial infarction, and major adverse cardiac events. To establish the functional effect of the IL-1RN6/2 (rs315951) polymorphism (principal IL-1 RN polymorp
Filiaciones:
Fragoso J.M.:
Univ Nacl Autonoma Mexico, Mexico City 04510, DF, Mexico
Delgadillo H.:
Interventional Cardiology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico
Llorente L.:
Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Chuquiure E.:
Coronary Unit, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico
Juárez-Cedillo T.:
Epidemiologic and Health Service Research Unit, Instituto Mexicano del Seguro Social, Mexico City, Mexico
Vallejo M.:
Sociomedical Department, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico
Lima G.:
Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Furuzawa-Carballeda J.:
Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Martínez-Ríos M.A.:
Interventional Cardiology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico
Vargas-Alarcón G.:
Dept. of Molecular Biology, Cardiovascular Disease's Genomic and Proteomic Study Group, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico
|