What happened after the initial global spread of pandemic human influenza virus A (H1N1)? A population genetics approach
Por:
Martinez-Hernandez F., Jimenez-Gonzalez D.E., Martinez-Flores A., Villalobos-Castillejos G., Vaughan G., Kawa-Karasik S., Flisser A., Maravilla P., Romero-Valdovinos M.
Publicada:
20 ago 2010
Resumen:
Viral population evolution dynamics of influenza A is crucial for surveillance and control. In this paper we analyzed viral genetic features during the recent pandemic caused by the new influenza human virus A H1N1, using a conventional population genetics approach based on 4689 hemagglutinin (HA) and neuraminidase (NA) sequences available in GenBank submitted between March and December of 2009. This analysis showed several relevant aspects: a) a scarce initial genetic variability within the viral isolates from some countries that increased along 2009 when influenza was dispersed around the world; b) a worldwide virus polarized behavior identified when comparing paired countries, low differentiation and high gene flow were found in some pairs and high differentiation and moderate or scarce gene flow in others, independently of their geographical closeness, c) lack of positive selection in HA and NA due to increase of the population size of virus variants, d) HA and NA variants spread i
Filiaciones:
Univ Nacl Autonoma Mexico, Dept Microbiol & Parasitol, Fac Med, Mexico City 04510, DF, Mexico
Departamento de Ecología de Agentes Patogenos, Hospital General Dr. Manuel Gea Gonzalez, Calzada de Tlalpan 4800, DF 14080, Mexico
Departamanto de Parasitologia, Escuela Nacional de Ciencias Biologicas, Instituto Politecnico Nacional, Prolongacián Carpio s/n, DF 11340, Mexico, Mexico
Departamento de Investigaciones Inmunologicas, Instituto de Diagnostico y Referencia Epidemiologicos, Carpio 470 SSA, DF 11340, Mexico
All Open Access, Gold
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