Risk Factors for Banff Borderline Acute Rejection in Protocol Biopsies and Effect on Renal Graft Function
Por:
Espinoza E.H., González-Parra C., Macias-Diaz, DM, Uribe-Uribe N.O., Alberú J., Morales-Buenrostro L.E.
Publicada:
1 jul 2010
Resumen:
Introduction. The interpretation and handling of Banff borderline acute rejection observed in protocol biopsies from patients with stable renal function continues to be controversial. Our objective was to identify the risk factors for borderline acute rejection on 1-year protocol biopsies and to evaluate their effect on renal graft function after 2 years' follow-up. Methods. We included 82 kidney transplant recipients (KTR), who underwent 1-year protocol biopsies with normal or stable graft function. All KTR had follow-up of at least 2 years posttransplantation. We formed three groups: (1) KTR with a normal biopsy, (2) KTR with borderline changes, and (3) KTR with interstitial fibrosis/tubular atrophy (IF/TA). We searched for risk factors related to borderline injury. The main outcome to evaluate was renal function at 1 month, at protocol biopsy, and 2 years posttransplant. Results. The 82 patients included in this study showed no differences in immunosuppression, gender, etiology of r
Filiaciones:
Espinoza E.H.:
Department of Nephrology and Mineral Metabolism, National Institute of Medical Sciences and Nutrition Salvador Zubirn, Mexico City, DF, Mexico
González-Parra C.:
Department of Nephrology and Mineral Metabolism, National Institute of Medical Sciences and Nutrition Salvador Zubirn, Mexico City, DF, Mexico
Uribe-Uribe N.O.:
Department of Pathology, National Institute of Medical Sciences and Nutrition Salvador Zubirn, Mexico City, DF, Mexico
Alberú J.:
Department of Transplantation, National Institute of Medical Sciences and Nutrition Salvador Zubirn, Mexico City, DF, Mexico
Morales-Buenrostro L.E.:
Department of Nephrology and Mineral Metabolism, National Institute of Medical Sciences and Nutrition Salvador Zubirn, Mexico City, DF, Mexico
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