Dopaminergic Modulation of Spiny Neurons in the Turtle Striatum
Por:
Barral J., Galarraga E., Tapia D., Flores-Barrera E., Reyes A., Bargas J.
Publicada:
1 jul 2010
Resumen:
Intracellular recordings were obtained from brain slice preparation in neurons of the striatum of the turtle Trachemys scripta elegans, analogous to the mammalian striatum in its topographic organization, synaptic connectivity, cytoarchitecture, and neurochemistry. Here we show that these similarities extend to the electrophysiological properties of its neurons. Biocytin staining revealed that 85% of the recorded neurons were medium spiny neurons while 15% were aspiny neurons. Spiny neurons of the turtle resembled those found in the mammalian and avian striatum and express dopaminergic D(1) and D(2) class receptors. Because the striatum of the turtle receives a dense dopaminergic innervation from tegmental dopaminergic neurons we investigated the postsynaptic actions of selective dopamine receptor agonists in the excitability of spiny neurons. As in mammals and birds, activation of D(1)-receptors enhances, whereas activation of D(2)-receptors decreases the evoked discharge. Apparently,
Filiaciones:
Barral J.:
Univ Nacl Autonoma Mexico, Dept Neurociencias, FES Iztacala, Mexico City 54090, DF, Mexico
Galarraga E.:
Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Dept Biofis, Mexico City 54090, DF, Mexico
Tapia D.:
Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Dept Biofis, Mexico City 54090, DF, Mexico
Flores-Barrera E.:
Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Dept Biofis, Mexico City 54090, DF, Mexico
Reyes A.:
Escuela de Biología, Benemerita Universidad Autönoma de Puebla, Puebla, Puebla, Mexico
Bargas J.:
Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Dept Biofis, Mexico City 54090, DF, Mexico
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