Potassium secretion by voltage-gated potassium channel Kv1.3 in the rat kidney
Por:
Carrisoza-Gaytan, R, Salvador, C, Satlin, LM, Liu, W, Zavilowitz, B, Bobadilla, NA, Trujillo, J, Escobar, LI
Publicada:
1 jul 2010
Resumen:
Carrisoza-Gaytan R, Salvador C, Satlin LM, Liu W, Zavilowitz B, Bobadilla NA, Trujillo J, Escobar LI. Potassium secretion by voltage-gated potassium channel Kv1.3 in the rat kidney. Am J Physiol Renal Physiol 299: F255-F264, 2010. First published April 28, 2010; doi: 10.1152/ajprenal.00697.2009.-The fine regulation of Na(+) and K(+) transport takes place in the cortical distal nephron. It is well established that K(+) secretion occurs through apical K(+) channels: the ROMK and the Ca2(+)- and voltage-dependent maxi-K. Previously, we identified the voltage-gated Kv1.3 channel in the inner medulla of the rat kidney (Escobar LI, Martinez-Tellez JC, Salas M, Castilla SA, Carrisoza R, Tapia D, Vazquez M, Bargas J, Bolivar JJ. Am J Physiol Cell Physiol 286: C965-C974, 2004). To examine the role of Kv1.3 in the renal regulation of K(+) homeostasis, we characterized the effect of dietary K(+) on the molecular and functional expression of this channel. We performed real-time-PCR and immunoblot
Filiaciones:
Carrisoza-Gaytan, R:
Univ Nacl Autonoma Mexico, Fac Med, Dept Fisiol, Mexico City 04510, DF, Mexico
Salvador, C:
Univ Nacl Autonoma Mexico, Fac Med, Dept Fisiol, Mexico City 04510, DF, Mexico
Bobadilla, NA:
Univ Nacl Autonoma Mexico, Unidad Fisiol Mol, Inst Invest Biomed, Mexico City 04510, DF, Mexico
Trujillo, J:
Univ Nacl Autonoma Mexico, Unidad Fisiol Mol, Inst Invest Biomed, Mexico City 04510, DF, Mexico
Escobar, LI:
Univ Nacl Autonoma Mexico, Fac Med, Dept Fisiol, Mexico City 04510, DF, Mexico
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