Clinical Comparison of Two Mexican Coccidioidins
Por:
Castanon-Olivares, LR, Laniado-Laborín R., Concepcion T., Munoz-Hernandez, B, Aroch-Calderón A., Aranda-Uribe I.S., Flores-Sánchez M.A., Gonzalez-Martinez, MD, Hernández-Navarez A., Manjarrez-Zavala M.E., Miranda-Mauricio S., Palma G., Pérez-Mejía A.
Publicada:
1 jun 2010
Resumen:
Coccidioidin, an extract from the saprophytic mycelial form of Coccidioides spp., has been a very useful antigen preparation both for skin and serological tests for coccidioidomycosis. Unfortunately, coccidioidin is not currently available for skin testing in the United States. Coccidioidin has been produced commercially in Mexico by a vaccine and reagents laboratory of the Mexican Federal Government. It also has been produced at the Microbiology Laboratory of the Faculty of Medicine, Universidad Nacional Autonoma de Mexico exclusively as an antigen for research projects. The objective of the study was to compare both coccidioidins in their reactivity and safety when applied in humans. One hundred and eighty-four volunteers were tested; median age was 33 (range 14-82). When the cutoff point is set in 5 mm, 88 subjects (47.8%) had a positive test for the commercial coccidioidin and 76 (41.3%; CI(95%) 0.50, 1.15; P = 0.20) were positive with the research antigen. Seventy-five subjects we
Filiaciones:
Castanon-Olivares, LR:
Univ Nacl Autonoma Mexico, Fac Med, Mexico City 04510, DF, Mexico
Laniado-Laborín R.:
Facultad de Medicina, Universidad Autónoma de Baja California, Emiliano Zapata 1423, Zona Centro., CP 22000 Tijuana, Baja California, Mexico
Concepcion T.:
Univ Nacl Autonoma Mexico, Fac Med, Mexico City 04510, DF, Mexico
Aroch-Calderón A.:
Univ Nacl Autonoma Mexico, Fac Med, Mexico City 04510, DF, Mexico
Aranda-Uribe I.S.:
Univ Nacl Autonoma Mexico, Fac Med, Mexico City 04510, DF, Mexico
Flores-Sánchez M.A.:
Univ Nacl Autonoma Mexico, Fac Med, Mexico City 04510, DF, Mexico
Gonzalez-Martinez, MD:
Univ Nacl Autonoma Mexico, Fac Med, Mexico City 04510, DF, Mexico
Hernández-Navarez A.:
Univ Nacl Autonoma Mexico, Fac Med, Mexico City 04510, DF, Mexico
Manjarrez-Zavala M.E.:
Univ Nacl Autonoma Mexico, Fac Med, Mexico City 04510, DF, Mexico
Miranda-Mauricio S.:
Univ Nacl Autonoma Mexico, Fac Med, Mexico City 04510, DF, Mexico
Palma G.:
Univ Nacl Autonoma Mexico, Fac Med, Mexico City 04510, DF, Mexico
Pérez-Mejía A.:
Univ Nacl Autonoma Mexico, Fac Med, Mexico City 04510, DF, Mexico
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