RNA interference (RNAi) and its therapeutic potential in cancer
Por:
Vazquez-Vega, S, Contreras-Paredes, A, Lizano-Soberon, M, Amador-Molina, A, Garcia-Carranca, A, Sanchez-Suarez, LP, Benitez-Bribiesca, L
Publicada:
1 ene 2010
Categoría:
Medicine (miscellaneous)
Resumen:
Small RNAs belong to a newly discovered strain of molecules These molecules are composed of double strand RNA comprised by just about 19-31 nucleotides They have two main characteristics that make them unique Firstly. they are non-coding for proteins and second they interfere post-transcriptional with in RNA This interfering action is the distinguishing hallmark. therefore known as interfering RNA or RNA, There are three main subclasses of which microRNA and siRNA are the most widely studied Interference RNAs participate in a myriad of cellular functions mainly through modulation of genetic expression Due to these capabilities it has been used as therapeutic weapon in a number of diseases including cancer It is known that both miRNA and siRNA participate in carcinogenesis. either inhibiting suppressor genes, or stimulating oncogenes It has been demonstrated that manipulating small interfering RNAs in cell lutes and animal models, the malignant and metastatic phenotype can be reversed U
Filiaciones:
Contreras-Paredes, A:
Univ Nacl Autonoma Mexico, Inst Nacl Cancerol, Inst Invest Biomed, Unidad Invest Biomed Canc, Mexico City 04510, DF, Mexico
Lizano-Soberon, M:
Univ Nacl Autonoma Mexico, Inst Nacl Cancerol, Inst Invest Biomed, Unidad Invest Biomed Canc, Mexico City 04510, DF, Mexico
Amador-Molina, A:
Univ Nacl Autonoma Mexico, Inst Nacl Cancerol, Inst Invest Biomed, Unidad Invest Biomed Canc, Mexico City 04510, DF, Mexico
Garcia-Carranca, A:
Univ Nacl Autonoma Mexico, Inst Nacl Cancerol, Inst Invest Biomed, Unidad Invest Biomed Canc, Mexico City 04510, DF, Mexico
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