Prevalence of human papillomavirus genotypes, and mucosal IgA anti-viral responses in women with cervical ectopy
Por:
Monroy O.L., Aguilar C., Lizano M., Cruz-Talonia F., Cruz R.M., Rocha-Zavaleta L.
Publicada:
1 ene 2010
Resumen:
Background: Data on the prevalence of different human papillomavirus (HPV) genotypes and the associated mucosal immune response in women with cervical ectopy are scarce. Objective: To assess the prevalence of different HPV genotypes and the mucosal anti-viral immune response in cervical ectopy. Study design: Detection and typing of HPV DNA was determined in 141 women with cervical ectopy, 272 cytologically normal controls and 98 low-grade squamous intraepithelial lesions (LSIL) by PCR and direct sequencing. Mucosal IgA antibodies to HPV16 and HPV18 were evaluated in cervical mucus by ELISA. Results: The prevalence of HPV in cervical ectopy was higher (73.7%) than that observed in control samples (30.5% in endocervix, and 1.8% in exocervix), but similar to the prevalence in LSIL (62.2%). Typing showed that the overall distribution frequency concerned 14 different genotypes, with HPV18 being the most prevalent in cervical ectopy (53.9%), whereas HPV16 predominated in LSIL (38.7%). High-r
Filiaciones:
Monroy O.L.:
Univ Nacl Autonoma Mexico, Dept Biol Mol & Biotecnol, Inst Invest Biomed, Mexico City 04510, DF, Mexico
Aguilar C.:
Univ Nacl Autonoma Mexico, Dept Biol Mol & Biotecnol, Inst Invest Biomed, Mexico City 04510, DF, Mexico
Lizano M.:
Univ Nacl Autonoma Mexico, Dept Biol Mol & Biotecnol, Inst Invest Biomed, Mexico City 04510, DF, Mexico
Cruz-Talonia F.:
Fundacion Cruz Talonia, Colegio Mexicano de Colposcopistas, Mexico D.F., Mexico
Cruz R.M.:
Fundacion Cruz Talonia, Colegio Mexicano de Colposcopistas, Mexico D.F., Mexico
Rocha-Zavaleta L.:
Univ Nacl Autonoma Mexico, Dept Biol Mol & Biotecnol, Inst Invest Biomed, Mexico City 04510, DF, Mexico
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