Geographical widespread of two lineages of Taenia solium due to human migrations: Can population genetic analysis strengthen this hypothesis?
Por:
Martinez-Hernandez F., Jimenez-Gonzalez D.E., Chenillo P., Alonso-Fernandez C., Maravilla P., Flisser A.
Publicada:
1 dic 2009
Resumen:
In this paper we discuss, with a new analysis of published data, the phylogenetic hypothesis of two genotypes of Taenia solium previously suggested. Sequences of mitochondrial (co1, cob, nad) and nuclear (18S+ITS1+5.8S, LMWA1 and LMWA2) T solium DNA from Africa, Asia, Latin America, and Oceania deposited in GenBank international databases were analyzed for diversity and genetic structure. Overall, we found that percentages of polymorphic and informative sites were comparatively less in mitochondrial genes, and minimum or null values of nucleotide diversity and nucleotide polymorphism were also observed. Analysis of co1 populations showed two associations of particular interest: Asia/Latin America and Africa/Latin America; with minimal differentiation between them and a constant genetic flow. Bayesian phylogenetic trees built with the available sequences for co1+cob showed two clusters, one for Asia and another one for Africa/Latin America while with ribosomal sequences only one cluster
Filiaciones:
Univ Nacl Autonoma Mexico, Fac Filosofia & Letras, Mexico City 04510, DF, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Dept Microbiol & Parasitol, Mexico City 04510, DF, Mexico
Departamento de Epidemiologia Molecular, Hospital General Dr. Manuel Gea Gonzalez, Mexico, 14080 D.F., Mexico
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