In Vitro and In Vivo Antiproliferative Activity of Laherradurin and Cherimolin-2 of Annona diversifolia Saff
Por:
Schlie-Guzmán M.A., García-Carrancá A., González-Esquinca A.R.
Publicada:
1 ago 2009
Categoría:
Pharmacology
Resumen:
Acetogenins from Annonaceae (ACG) are potent inhibitors of the mitochondrial complex 1, they present cytotoxic activity on neoplasic lines, including those with multiresistance to drugs. In vivo antitumor activities of some ACG have been reported; however, no information is available regarding the relationship between their cytotoxic activity in cell cultures and their antiproliferative action in vivo. Laherradurin and cherimolin-2 acetogenins were isolated from Annona diversifolia seeds, and their inhibitory potential was analysed in vitro on HeLa and SW-480 cells. Doses containing 1, 10, 100 and 500 times the IC(50) obtained from the proliferation assays and multiplied by the weight of the animal, were injected once daily into athymic mice bearing these cancer cell lines; their effect upon tumor growth was measured over a period of 20 days. Laherradurin was more active than cherimolin-2, and it showed in in vitro proliferation assays a similar IC(50) in both neoplasic lines. In athym
Filiaciones:
Schlie-Guzmán M.A.:
Escuela de Biología, Universidad de Ciencias Y Artes de Chiapas, Libramiento Norte Poniente s/n, CP 29039, Tuxtla Gutiérrez, Chiapas, Mexico
García-Carrancá A.:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mexico City 04510, DF, Mexico
SSA, Unidad Invest Biomed Canc, Inst Nacl Cancerol, Mexico City 14080, DF, Mexico
González-Esquinca A.R.:
Escuela de Biología, Universidad de Ciencias Y Artes de Chiapas, Libramiento Norte Poniente s/n, CP 29039, Tuxtla Gutiérrez, Chiapas, Mexico
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