Quantification of lysine clonixinate in intravenous injections by NIR spectroscopy
Por:
López-Arellano R., Santander-García E.A., Andrade-Garda J.M., Alvarez-Avila G., Garduno-Rosas, JA, Morales-Hipólito E.A.
Publicada:
10 nov 2009
Categoría:
Spectroscopy
Resumen:
Migraine is a very painful and somewhat unpredictable ache that affects millions of people worldwide and for which no definite medicine exists, yet. New drugs and/or pharmaceutical forms are being developed, for which new quantitation methods are required. Lysine clonixinate (LC) has proved very advantageous to alleviate migraine episodes although, so far, no analytical procedures have been reported to quantify it in pharmaceutical dosage forms usually employed by physicians, i.e., injectable solutions. In this paper a NIR spectral method was developed and validated against international pharmaceutical standard guidelines and a new UV-based method to quantify LC in intravenous injection solutions. Both methods are almost inexpensive, fast, simple and suitable for LC routine determination. In addition, they provide analytical protocols less time-consuming than other reported HPLC methods (developed for other matrices), proved to be specific, accurate, precise and linear within the typic
Filiaciones:
López-Arellano R.:
Univ Nacl Autonoma Mexico, FES Cuautitlan, LEDEFAR, Unidad Multidisciplinaria Invest, Cuautitlan 54700, Edo De Mexio, Mexico
Santander-García E.A.:
Univ Nacl Autonoma Mexico, FES Cuautitlan, LEDEFAR, Unidad Multidisciplinaria Invest, Cuautitlan 54700, Edo De Mexio, Mexico
Andrade-Garda J.M.:
Dept. of Analytical Chemistry, University of A Coruña, Campus da Zapateira s/n, 15071 A Coruña, Spain
Alvarez-Avila G.:
Univ Nacl Autonoma Mexico, FES Cuautitlan, LEDEFAR, Unidad Multidisciplinaria Invest, Cuautitlan 54700, Edo De Mexio, Mexico
Garduno-Rosas, JA:
Univ Nacl Autonoma Mexico, FES Cuautitlan, LEDEFAR, Unidad Multidisciplinaria Invest, Cuautitlan 54700, Edo De Mexio, Mexico
Morales-Hipólito E.A.:
Univ Nacl Autonoma Mexico, FES Cuautitlan, LEDEFAR, Unidad Multidisciplinaria Invest, Cuautitlan 54700, Edo De Mexio, Mexico
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