Lack of pathogenicity and toxicity of the mycoinsecticide Metarhizium anisopliae var. acridum following acute gastric exposure in mice
Por:
Toriello C., Pérez-Torres A., Vega-García F., Navarro-Barranco H., Pérez-Mejía A., Lorenzana-Jiménez M., Hernández-Velázquez V., Mier T.
Publicada:
1 nov 2009
Resumen:
Metarhizium anisopliae var. acridum, monospore culture EH-502/8 (CNRCB MaPL40), isolated in Mexico from Schistocerca piceifrons ssp. piceifrons (Orthoptera: Acrididae) was tested for acute oral intragastric pathogenicity and toxicity in CD-I mice. Animals were inoculated with one dose (10(8) conidia/animal) of viable (72 mice), non-viable (24 mice) conidia and compared to 18 control mice. Clinical observations were done daily; mycological and histological tests were performed during necropsies after the inoculation. No mice showed clinical symptoms of illness or died during the study. The fungus was able to persist in some organs until day 3, but did not cause any damage to the host. The gross pathology observed was splenomegaly in mice inoculated with viable and non-viable conidia. Non-germinated conidia, observed in several organs, suggest hematogenous spread, but without any histopathological tissue reaction. Results support the non-pathogenic and non-toxic status of this fungal str
Filiaciones:
Toriello C.:
Univ Nacl Autonoma Mexico, Dept Microbiol & Parasitol, Fac Med, Mexico City 04510, DF, Mexico
Pérez-Torres A.:
Univ Nacl Autonoma Mexico, Dept Biol Celular & Tisular, Fac Med, Mexico City 04510, DF, Mexico
Vega-García F.:
Univ Nacl Autonoma Mexico, Dept Microbiol & Parasitol, Fac Med, Mexico City 04510, DF, Mexico
Navarro-Barranco H.:
Univ Nacl Autonoma Mexico, Dept Microbiol & Parasitol, Fac Med, Mexico City 04510, DF, Mexico
Pérez-Mejía A.:
Univ Nacl Autonoma Mexico, Dept Microbiol & Parasitol, Fac Med, Mexico City 04510, DF, Mexico
Lorenzana-Jiménez M.:
Univ Nacl Autonoma Mexico, Dept Farmacol, Fac Med, Mexico City 04510, DF, Mexico
Hernández-Velázquez V.:
Centro de Investigación en Biotecnología, Universidad Autónoma del Estado de Morelos, Cuernavaca, 62209, Mexico
Mier T.:
Departamento El Hombre y su Ambiente, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana-Xochimilco, México D.F. 04960, Mexico
|