Tumor cell energy metabolism and its common features with yeast metabolism
Por:
Diaz-Ruiz R., Uribe-Carvajal S., Devin A., Rigoulet M.
Publicada:
1 dic 2009
Resumen:
During the last decades a considerable amount of research has been focused on cancer. A number of genetic and signaling defects have been identified. This has allowed the design and screening of a number of anti-tumor drugs for therapeutic use. One of the main challenges of anti-cancer therapy is to specifically target these drugs to malignant cells. Recently, tumor cell metabolism has been considered as a possible target for cancer therapy. It is widely accepted that tumors display an enhanced glycolytic activity and oxidative phosphorylation down-regulation (Warburg effect). Therefore, it seems reasonable that disruption of glycolysis might be a promising candidate for specific anti-cancer therapy. Nonetheless, the concept of aerobic glycolysis as the paradigm of tumor cell metabolism has been challenged, as some tumor cells use oxidative phosphorylation. Mitochondria are of special interest in cancer cell energy metabolism, as their physiology is linked to the Warburg effect. Beside
Filiaciones:
Univ Nacl Autonoma Mexico, Dept Bioquim, Inst Fisiol Celular, Mexico City 04510, DF, Mexico
CNRS, Institute of Biochemistry and Genetics of the Cell (IBGC), UMR 5095, 1 rue Camille Saint Saëns, 33077 Bordeaux cedex, France
Université Bordeaux 2, 1 rue Camille, Saint Saëns, 33077 Bordeaux cedex, France
Instituto de Fisiología Celular, Departamento de Bioquímica, Universidad Nacional Autonoma de Mexico, Apartado Postal 70-600, Ciudad Universitaria, Mexico
|