Estrogen receptor regulates MyoD gene expression by preventing AP-1-mediated repression
Por:
Pedraza-Alva G., Zingg J.M., Donda A., Pérez-Martínez L.
Publicada:
13 nov 2009
Resumen:
Cell growth and differentiation are opposite events in the myogenic lineage. Growth factors block the muscle differentiation program by inducing the expression of transcription factors that negatively regulate the expression of muscle regulatory genes like MyoD. In contrast, extracellular clues that induce cell cycle arrest promote MyoD expression and muscle differentiation. Thus, the regulation of MyoD expression is critical for muscle differentiation. Here we show that estrogen induces MyoD expression in mouse skeletal muscle in vivo and in dividing myoblasts in vitro by relieving the MyoD promoter from AP-1 negative regulation through a mechanism involving estrogen receptor/AP-1 protein-protein interactions but independent of the estrogen receptor DNA binding activity. (C) 2009 Elsevier Inc. All rights reserved.
Filiaciones:
Pedraza-Alva G.:
Univ Nacl Autonoma Mexico, Inst Biotecnol, Cuernavaca 62250, Morelos, Mexico
Zingg J.M.:
Institute of Biochemistry and Molecular Biology, University of Bern, Bern, Switzerland
Donda A.:
Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
Pérez-Martínez L.:
Univ Nacl Autonoma Mexico, Inst Biotecnol, Cuernavaca 62250, Morelos, Mexico
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