Adrenalectomy prevents renal ischemia-reperfusion injury
Por:
Ramirez, V, Trujillo, J, Valdes, R, Uribe, N, Cruz, C, Gamba, G, Bobadilla, NA
Publicada:
1 oct 2009
Resumen:
Ramirez V, Trujillo J, Valdes R, Uribe N, Cruz C, Gamba G, Bobadilla NA. Adrenalectomy prevents renal ischemia-reperfusion injury. Am J Physiol Renal Physiol 297: F932-F942, 2009. First published August 5, 2009; doi: 10.1152/ajprenal. 00252.2009.-Spironolactone treatment prevents renal damage induced by ischemia-reperfusion (I/R), suggesting that renoprotection conferred by spironolactone is mediated by mineralocorticoid receptor (MR) blockade. It is possible, however, that this effect is due to other mechanisms. Therefore, this study evaluated whether adrenalectomy prevented renal damage induced by I/R. Three groups of Wistar rats were studied: 1) a group subjected to a sham surgery, 2) a group subjected to bilateral I/R, and 3) a group of rats in which adrenal glands were removed 3 days before induction of I/R. As expected, I/R resulted in renal dysfunction and severe tubular injury that was associated with a significant increase in tubular damage markers. In contrast, there was no r
Filiaciones:
Ramirez, V:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mol Physiol Unit, Mexico City 04510, DF, Mexico
Trujillo, J:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mol Physiol Unit, Mexico City 04510, DF, Mexico
Valdes, R:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mol Physiol Unit, Mexico City 04510, DF, Mexico
Gamba, G:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mol Physiol Unit, Mexico City 04510, DF, Mexico
Bobadilla, NA:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mol Physiol Unit, Mexico City 04510, DF, Mexico
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