Effect of pro-inflammatory cytokine stimulation on human breast cancer: Implications of chemokine receptor expression in cancer metastasis
Por:
Valdivia-Silva J.E., Franco-Barraza J., Silva, ALE, Du Pont, G, Soldevila G., Meza I., García-Zepeda E.A.
Publicada:
8 oct 2009
Resumen:
Interactions between turnout cells and microenvironments may affect their growth and metastasis formation. in search for a better understanding of the role of cellular mediators in the progression of cancer, we investigated the effect of pro-inflammatory cytokines IL-1, IL-6, TNF-alpha and IFN-gamma on the regulation of expression of chemokine receptors CXCR4, CXCR2, CX3CR1, CCR9, and CCR5 in the human breast cancer cell line MCF-7. Our results showed that IL-1 increased CXCR4 expression whereas TNF-alpha increased CX3CR1, CCR9 and CCR5. Interestingly, this regulation was not homogeneous, emphasizing the inherent heterogeneity in cancer that may be responsive to specific inflammatory microenvironments. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
Filiaciones:
Valdivia-Silva J.E.:
Univ Nacl Autonoma Mexico, Dept Inmunol, Inst Invest Biomed, Mexico City 04510, DF, Mexico
Franco-Barraza J.:
Departamento de Biomedicina Molecular, CINVESTAV-IPN, México, DF, Mexico
Silva, ALE:
Univ Nacl Autonoma Mexico, Dept Inmunol, Inst Invest Biomed, Mexico City 04510, DF, Mexico
Du Pont, G:
Univ Nacl Autonoma Mexico, Dept Inmunol, Inst Invest Biomed, Mexico City 04510, DF, Mexico
Soldevila G.:
Univ Nacl Autonoma Mexico, Dept Inmunol, Inst Invest Biomed, Mexico City 04510, DF, Mexico
Meza I.:
Departamento de Biomedicina Molecular, CINVESTAV-IPN, México, DF, Mexico
García-Zepeda E.A.:
Univ Nacl Autonoma Mexico, Dept Inmunol, Inst Invest Biomed, Mexico City 04510, DF, Mexico
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