Muscarinic Enhancement of Persistent Sodium Current Synchronizes Striatal Medium Spiny Neurons
Por:
Carrillo-Reid, L, Tecuapetla, F, Vautrelle, N, Hernandez, A, Vergara, R, Galarraga, E, Bargas, J
Publicada:
1 ago 2009
Resumen:
Carrillo-Reid L, Tecuapetla F, Vautrelle N, Hernandez A, Vergara R, Galarraga E, Bargas J. Muscarinic enhancement of persistent sodium current synchronizes striatal medium spiny neurons. J Neurophysiol 102: 682-690, 2009. First published May 27, 2009; doi:10.1152/jn.00134.2009. Network dynamics denoted by synchronous firing of neuronal pools rely on synaptic interactions and intrinsic properties. In striatal medium spiny neurons, N-methyl-D-aspartate (NMDA) receptor activation endows neurons with nonlinear capabilities by inducing a negative-slope conductance region (NSCR) in the current-voltage relationship. Nonlinearities underlie associative learning, procedural memory, and the sequential organization of behavior in basal ganglia nuclei. The cholinergic system modulates the function of medium spiny projection neurons through the activation of muscarinic receptors, increasing the NMDA-induced NSCR. This enhancement is reflected as a change in the NMDA-induced network dynamics, making
Filiaciones:
Carrillo-Reid, L:
Univ Nacl Autonoma Mexico, Dept Biofis, Inst Fisiol Celular Neurociencias, Mexico City 04510, DF, Mexico
Tecuapetla, F:
Univ Nacl Autonoma Mexico, Dept Biofis, Inst Fisiol Celular Neurociencias, Mexico City 04510, DF, Mexico
Vautrelle, N:
Univ Nacl Autonoma Mexico, Dept Biofis, Inst Fisiol Celular Neurociencias, Mexico City 04510, DF, Mexico
Hernandez, A:
Univ Nacl Autonoma Mexico, Dept Biofis, Inst Fisiol Celular Neurociencias, Mexico City 04510, DF, Mexico
Vergara, R:
Univ Nacl Autonoma Mexico, Dept Biofis, Inst Fisiol Celular Neurociencias, Mexico City 04510, DF, Mexico
Galarraga, E:
Univ Nacl Autonoma Mexico, Dept Biofis, Inst Fisiol Celular Neurociencias, Mexico City 04510, DF, Mexico
Bargas, J:
Univ Nacl Autonoma Mexico, Dept Biofis, Inst Fisiol Celular Neurociencias, Mexico City 04510, DF, Mexico
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