Cortisol controlled release by mesoporous silica
Por:
Lopez T., Ortiz E., Alexander-Katz R., Basaldella E., Bokhimi X.
Publicada:
1 jun 2009
Resumen:
In this study four types of SBAs were synthesized and then impregnated with hydrocortisone. One is a straight SBA-15, obtained using Pluronics P123 as structuring agent; two others were modified using 1,3,5-trimethylbenzene as additive, and the fourth one was prepared using sodium iodide as additive. Three of these have in common a p6mm symmetry with nanotubes packed hexagonally, yet they differ in their functional groups. The fourth sample is basically disordered. The drug release kinetics showed two stages: a fast-rate early stage dominated by the controlled release of the hydrocortisone adsorbed in the macropores of the reservoir, followed by a slow-rate delivery that we assume is controlled by the hydrocortisone diffusion through the nanopores. It is shown that the release kinetics can be strongly influenced by using different co-additives. (C) 2009 Elsevier Inc. All rights reserved.
Filiaciones:
Univ Autonoma Metropolitana Xochimilco, Dept Atenc Salud, Mexico City, DF, Mexico
Univ Nacl Autonoma Mexico, Inst Fis, Mexico City 01000, DF, Mexico
Instituto Nacional de Neurología y Neurocirugía MVS, México DF, Mexico
Departamento de Física, Universidad Autónoma Metropolitana-Iztapalapa, México DF, Mexico
CIC-CINDECA-Universidad Nacional de La Plata, La Plata, Argentina
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