Inhibitory Contribution to Suprathreshold Corticostriatal Responses: An Experimental and Modeling Study
Por:
Flores-Barrera, E, Laville, A, Plata, V, Tapia, D, Bargas, J, Galarraga, E
Publicada:
1 jul 2009
Resumen:
Neostriatal neurons may undergo events of spontaneous synchronization as those observed in recurrent networks of excitatory neurons, even when cortical afferents are transected. It is necessary to explain these events because the neostriatum is a recurrent network of inhibitory neurons. Synchronization of neuronal activity may be caused by plateau-like depolarizations. Plateau-like orthodromic depolarizations that resemble up-states in medium spiny neostriatal neurons (MSNs) may be induced by a single corticostriatal suprathreshold stimulus. Slow synaptic depolarizations may last hundreds of milliseconds, decay slower than the monosynaptic glutamatergic synaptic potentials that induce them, and sustain repetitive firing. Because inhibitory inputs impinging onto MSNs have a reversal potential above the resting membrane potential but below the threshold for firing, they conform a type of "shunting inhibition". This work asks if shunting GABAergic inputs onto MSNs arrive asynchronously en
Filiaciones:
Flores-Barrera, E:
Univ Nacl Autonoma Mexico, Dept Biofis, Inst Fisiol Celular Neurociencias, Mexico City 04510, DF, Mexico
Laville, A:
Univ Nacl Autonoma Mexico, Dept Biofis, Inst Fisiol Celular Neurociencias, Mexico City 04510, DF, Mexico
Plata, V:
Univ Nacl Autonoma Mexico, Dept Biofis, Inst Fisiol Celular Neurociencias, Mexico City 04510, DF, Mexico
Tapia, D:
Univ Nacl Autonoma Mexico, Dept Biofis, Inst Fisiol Celular Neurociencias, Mexico City 04510, DF, Mexico
Bargas, J:
Univ Nacl Autonoma Mexico, Dept Biofis, Inst Fisiol Celular Neurociencias, Mexico City 04510, DF, Mexico
Galarraga, E:
Univ Nacl Autonoma Mexico, Dept Biofis, Inst Fisiol Celular Neurociencias, Mexico City 04510, DF, Mexico
|