Aging increases the susceptibility to develop anhedonia in male rats
Por:
Herrera-Pérez J.J., Martínez-Mota L., Fernández-Guasti A.
Publicada:
12 dic 2008
Resumen:
The objective of this study was to establish the effect of aging on the development of anhedonia, a core feature of depression. Young and old male Wistar rats (of around 3-5 and 12-15 months, respectively) were exposed to a chronic variable stress (CVS) schedule for 3 weeks. CVS produced anhedonia, indicated by a reduction in the intake of a sucrose solution (1%), in 8 out of 23 (35%) young rats and in 19 out of 26 (73%) old rats, implying that old animals are more susceptible to stress and develop anhedonia more readily than young animals. Young and old anhedonic rats showed a similar temporal course in the reduction of sucrose consumption, reaching the anhedonic state after 2 weeks of CVS exposure. Compared with young animals, old rats had lower basal serum testosterone and estradiol levels. The systemic levels of corticosterone did not vary between both age groups. No significant pathological condition was detected in old animals. It is suggested that the higher susceptibility to develop anhedonia in male rats could be associated to neuroendocrine changes consequent to aging. © 2008 Elsevier Inc. All rights reserved.
Filiaciones:
Herrera-Pérez J.J.:
Farmacología Conductual, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México-Xochimilco 101, Col. San Lorenzo Huipulco, Tlalpan, CP: 14370, Mexico City, Mexico
Departamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados, IPN, Calzada los Tenorios 235, Col. Granjas Coapa, Tlalpan, CP: 14330 Mexico City, Mexico
Martínez-Mota L.:
Farmacología Conductual, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México-Xochimilco 101, Col. San Lorenzo Huipulco, Tlalpan, CP: 14370, Mexico City, Mexico
Fernández-Guasti A.:
Departamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados, IPN, Calzada los Tenorios 235, Col. Granjas Coapa, Tlalpan, CP: 14330 Mexico City, Mexico
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